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Could a simple pacemaker tweak help heart shock patients?

NCT ID NCT06713668

Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether increasing the backup pacing rate from 75 to 100 beats per minute improves blood flow in adults with cardiogenic shock who already have a permanent pacemaker. Twenty-five participants in the cardiac ICU will be exposed to both rates in random order, with measurements taken after 10 minutes at each setting. The goal is to see if a faster rate can help stabilize their condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
backup pacing rate change (device intervention)
What this could lead to
If it works, this could point toward a simple pacemaker adjustment to help stabilize blood flow in critically ill heart patients.
What could go wrong
This is a very small pilot study (25 people) testing only short-term effects (10 minutes per rate). It may not show meaningful benefit or translate to real-world outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (age 18 and older) * Located in the CVICU * FDA approved permanent pacemaker in place (inclusive of dual-chamber and Bi-Ventricular ICDs) with labeling that allows backup pacing setting at 100 bpm. * Receiving a vasopressor or Inotrope for at least 4 hours * Average HR ≤ 75 bpm over the last hour (on Telemetry review) * Pulmonary artery catheter in place with functioning thermistor and pulmonary artery port. Exclusion Criteria: * Single chamber Implantable Cardiac Defibrillator * Sinus rhythm with a leadless pacemaker * Ventricular Tachycardia or Ventricular Fibrillation arrest in last 48 hours * Hemodynamic instability within the last 4 hours, defined as an increase in the dose of norepinephrine \> 10 mcg/min, an increase of epinephrine \> 10 mcg/kg/min, or initiation of a second vasopressor * Alternative indication for pacing rate change (i.e Torsade de Pointes, Recurrent Ventricular Tachycardia) * Comfort-focused care or anticipated death within 24 hours * Mechanical circulatory support in place * Newly discovered pacing system malfunction (lead displacement, loss of capture, elevated capture threshold, significant lead impedance change, battery depletion, undersensing or oversensing) * Non-English Speaking

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Conditions

The condition(s) this trial relates to.

Bradycardia cardiogenic shock Shock Shock, Cardiogenic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bradycardia Cardiogenic shock Shock

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.