Heart scarring may foretell Post-Surgery rhythm problems
NCT ID NCT05014802
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether scarring (fibrosis) in the heart's upper chambers can predict who will develop an irregular heartbeat after heart surgery. Researchers will track 50 adults aged 40+ with no prior irregular heartbeat who are scheduled for heart surgery. The goal is to see if more scarring leads to higher risk, which could help doctors better prevent and manage this common complication.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2021
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population is any patient with no history of atrial arrhythmia scheduled to undergo cardiac surgery and meets other inclusion/exclusion criteria). Each Site: * Approximately 10 Patients from either Tulane Medical Center and/or University Medical Center New Orleans. * Approximately 40 Patients from Washington University Medical Center (Barnes Jewish Hospital). The PIs and co-PI will have access to recruit patients through their cardiology and cardiothoracic surgery clinics. Participants may also be recruited from the community by direct advertising; emails, TV, flyers posted in public places, as well as online postings to study-site affiliated websites, social media platforms (Facebook, Twitter, Instagram) and LinkedIn.
- Ages
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40 to 120 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female patients age 40 years of age or older * Patients with no history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia) scheduled to undergo cardiac surgery (These surgeries include but are not limited to coronary artery bypass graft (CABG), valvular repair/reconstruction, aneurysm repair, and insertion of pacemaker). Exclusion Criteria: * Patients with a history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia) * Patients with a history of cardiac or open chest surgery * Patients with a history of catheter ablation * Patients under the age of 40 * Patients with left ventricular assist device (LVAD) or scheduled to have LVAD implanted * Patients who have previously undergone extracorporeal membrane oxygenation (ECMO) * Patients who have undergone or will undergo heart transplantation * Patients with any health related Late Gadolinium Enhancement (LGE)-MRI contraindications (including previous allergic reaction to gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI) * Acute or chronic severe renal disease with a low glomerular filtration rate (GFR), \<30 mL per minute per 1.73 m2 will be excluded from the trial. (A creatinine measurement should be available within the last 6 months. If not, a creatinine blood test will be drawn to assess for renal function before the MRI acquisition). * Patients weighing \> 300 lbs. (MRI image quality decreases due to increased body mass index) * Patients currently pregnant or breastfeeding, or plan to become pregnant during the study period * Patients with cognitive impairment preventing them from giving informed consent will be excluded from the study * Patients who cannot read, speak, and/or understand English
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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East Jefferson General Hospital
RECRUITINGNew Orleans, Louisiana, 70006, United States
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Lakeview Hospital
RECRUITINGCovington, Louisiana, 70433, United States
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Washington University Barnes-Jewish Hospital
RECRUITINGSt Louis, Missouri, 63110, United States
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