5,000-Person study aims to take guesswork out of depression treatment

NCT ID NCT07528014

Knowledge-focused Sponsor: Salma Health, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will collect data from 5,000 adults with depressed mood who are receiving esketamine, TMS, or SAINT therapy in routine care. Researchers will analyze this information to build models that could one day predict which treatment is most likely to help a given patient. The goal is to move toward more personalized depression care, but the study itself does not test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this could lead to tools that help doctors choose the best depression treatment for each person, improving outcomes.
What could go wrong: This is an observational study, not a treatment trial. The predictive models may not prove accurate enough for real-world use, and results may take years to develop.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 5,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Mar 2037

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will enroll up to 5,000 adult participants who are presenting for care with depressed mood and are prescribed and intending to receive standard-of-care treatment with esketamine, conventional TMS or SAINT.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 years) of any gender identity presenting for care with a depressed mood. * Prescribed treatment with esketamine, conventional TMS, or SAINT as part of standard clinical care. * Able to provide informed consent and comply with all study requirements. Exclusion Criteria: * Any condition deemed by the investigator to preclude safe participation in study assessments.

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Conditions

The condition(s) this trial relates to.

Consciousness Disorders Depression Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depressed mood

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

5,000-Person study aims to take guesswork out of depression treatment

What the study statuses mean