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Could ambulance asthma treatment keep kids out of the hospital?

NCT ID NCT06074185

Symptom relief Sponsor: Oregon Health and Science University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether giving two asthma medications (ipratropium and dexamethasone) to children during ambulance transport can reduce hospital admissions. The study included 44 children aged 2 to 17 with severe wheezing. The goal was to see if this early treatment is feasible and effective in real-world emergency settings.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ipratropium bromide and dexamethasone
What this could lead to
If successful, this approach could help children with severe asthma attacks get faster relief and avoid hospitalization.
What could go wrong
This is a small pilot study with only 44 participants, so results may not apply broadly. The treatments are already used in hospitals, but their benefit in ambulances is still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

44 people

The number who actually took part.

Started

Jan 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Ages 2-17 years; AND 2. Transported by EMS through 911 activation; AND 3. Prior history of wheeze/asthma, current asthma symptoms (dyspnea or wheeze); AND 4. At least 4 of the following: * Visible use of accessory muscles/retractions * Inspiratory and expiratory wheezing or silent chest * Abnormal respiratory rate for age * For \< 6 years ≥ 46 breaths/min * For ≥ 6 years ≥ 36 breaths/min * Agitation, drowsiness, or confusion * Oxygen saturation \< 93% on room air Exclusion Criteria: 1. History of albuterol, ipratropium, or dexamethasone allergy 2. Known or suspected pregnancy 3. Prisoner 4. Croup 5. Suspected airway foreign body 6. Respiratory distress not due to bronchospasm/wheeze 7. Parent, legally authorized representative (LAR), subject, and/or family member objects to participation prior to treatment

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Conditions

The condition(s) this trial relates to.

acute asthma asthma childhood onset asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma in children

Contacts and locations

Locations

  • Mecklenburg County EMS

    Charlotte, North Carolina, 28208, United States

  • University at Buffalo

    Buffalo, New York, 14261, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

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