Aspirin dilemma: to stop or not to stop during brain bleed treatment?
NCT ID NCT07240454
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether people with a chronic subdural hematoma (a slow brain bleed) who are already taking aspirin should continue or stop it while receiving non-surgical care. Researchers will follow 143 participants for 6 months to see if the hematoma comes back or worsens. The goal is to provide better guidance on managing aspirin use in this situation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Aspirin
- What this could lead to
- If it works, this could help doctors give clearer guidance on whether to keep taking aspirin during conservative treatment for chronic subdural hematoma, potentially reducing the risk of the hematoma coming back or getting worse.
- What could go wrong
- This is a relatively small trial (143 people) and is not a late-stage study, so results may not apply to everyone. The main risk is that continuing aspirin might increase bleeding, while stopping it could raise the chance of a heart attack or stroke.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 143 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years, male or female; * Confirmed diagnosis of chronic subdural hematoma (cSDH) by cranial CT and/or MRI; * Intended for conservative management (i.e., no surgical evacuation indication at enrollment); * Regular aspirin use at enrollment; * Informed consent signed by the patient or legal representative. Exclusion Criteria: * Patients requiring emergency surgery to remove hematoma at enrollment; * Concurrent use of other anticoagulants or antiplatelet agents that cannot be discontinued according to the study protocol; * cSDH secondary to other diseases or conditions (e.g., excessive drainage from ventriculoperitoneal shunts, intracranial tumors); * Active bleeding events or major cardiac events (e.g., acute myocardial infarction, unstable angina, or revascularization surgery) within 30 days prior to enrollment; * Known bleeding disorders (e.g., hemophilia, severe thrombocytopenia); * Individuals unable to provide informed consent or for whom completion of follow-up is anticipated to be difficult.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Tianjin Medical University General Hospital
RECRUITINGTianjin, China
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Xuanwu Hospital Capital Medical University
RECRUITINGBeijing, China
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