Herbal hope: ashwagandha supplement put to the test for weight loss and stress relief
NCT ID NCT07215455
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a daily 300 mg dose of KSM66 ashwagandha root extract can help overweight and obese adults manage their weight and stress. Fifty participants took either the supplement or a placebo for 8 weeks. Researchers measured changes in body weight, BMI, and perceived stress levels to see if the herb makes a real difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ashwagandha root extract (KSM66)
- What this could lead to
- If it works, this could point toward a natural supplement option for supporting weight management and reducing stress in overweight adults.
- What could go wrong
- This is a small, completed trial with only 50 participants, so results may not apply to everyone. As a dietary supplement, effects are likely modest and not a substitute for diet and exercise.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
50 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Oct 2025
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy adult men and women participants ≥ 19 years and ≤65 years of age. 2. Willingness to follow the protocol requirements as evidenced by written informed consent. 3. Participants willing to give meaningful, written informed consent prior to participation in the trial, in accordance with regulatory requirements. 4. Participants who agree to take investigational product (i.e., Till Week 8). 5. Participants with Body mass index between 25 and 39.9 kg/m2 Exclusion Criteria: 1. History of Alcohol or smoking abuse. 2. History of hypersensitivity to Ashwagandha 3. Taking nutritional or energy supplements, medication, or steroids, 4. Any history of drug abuse 5. Having any clinical abnormalities 6. Simultaneously participating in any other clinical trial or participated in the past three months 7. Participants who use medication for blood pressure, use beta-blockers, inhaled any beta-agonists, use any hormonal contraceptives, having a history of corticosteroid use within three months, participants under psychotropic medication within last 8 weeks 8. Participants diagnosed with any heart disease, diabetes, stroke, neurological disorders or depression. 9. Have clinically significant acute unstable hepatic, renal, cardiovascular, or respiratory disease that will prevent participation in the study. 10. Patients with depressive episode, panic disorder, social phobia, obsessive-compulsory disorder, alcohol dependency; schizophrenia and mania. 11. Patients with post traumatic disorder. 12. Have an established practice of meditation (as meditating for at least 20 minutes, three or more times per week) for three or more months. 13. Pregnant and lactating women 14. Participation in other clinical trials during previous 3 months 15. Any clinical condition, according to the investigator which does not allow safe fulfilment of clinical trial protocol.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
San Francisco Research Institute
San Francisco, California, 94132, United States
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