Steroid showdown: which strategy prevents adrenal crisis after surgery?
NCT ID NCT07558135
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways of managing steroid replacement after adrenalectomy (removal of an adrenal gland). One approach gives steroids to everyone right after surgery, while the other withholds them if a morning blood test shows normal cortisol levels. The goal is to see which method better prevents adrenal insufficiency, a condition where the body can't make enough stress hormones. The trial will follow 96 patients for three months after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hydrocortisone
- What this could lead to
- If successful, this trial could establish a clearer, safer approach to steroid use after adrenalectomy, reducing the risk of adrenal insufficiency and life-threatening adrenal crisis.
- What could go wrong
- This is a relatively small, single-center trial that has not yet started recruiting. The results may not apply to all patients, and the best management strategy may still depend on individual factors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 96 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Sep 2026
An estimate. Start dates often move.
- Expected to finish
-
Dec 2028
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Recommended for adrenalectomy following adrenal multidisciplinary discussion * ≥18 years old * Ability to consent Exclusion Criteria: * Overt Cushing's syndrome * Pregnancy * Pre-existing confirmed adrenal insufficiency * Pre-existing steroid therapy (including high dose steroid inhalers) * History of adrenalectomy * Bilateral disease as assessed radiologically and clinically
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Adrenal gland disease are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.