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Can arginine and glutamine soothe radiation mouth pain?

NCT ID NCT07020754

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether mouth rinses containing the amino acids arginine or glutamine could reduce the severity of painful mouth sores caused by radiation therapy in head and neck cancer patients. 69 participants swished and swallowed these supplements three times daily during weeks 2 to 7 of their radiation treatment. Researchers measured inflammation markers, pain levels, and quality of life to see if either supplement helped more than a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
L-arginine and L-glutamine oral suspensions
What this could lead to
If effective, these amino acid mouth rinses could offer a simple, low-cost way to reduce pain and speed healing of radiation-induced mouth sores.
What could go wrong
This is a small Phase 2 trial with only 69 participants, so results may not apply to everyone. The supplements may not outperform the placebo, and any benefit might be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

84 people

The number who actually took part.

Started

Apr 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 20 and 70 years Diagnosed with head and neck cancer (HNC) and undergoing radiotherapy (RT) Development of oral mucositis during the 2nd to 3rd week of RT Receiving a minimum radiation dose of 50 Gy to the oral cavity Undergoing intensity-modulated radiotherapy (IMRT) with three-dimensional conformal techniques after complete tumor resection Ability and willingness to provide informed consent Able to comply with study procedures and follow-up assessments Exclusion Criteria: * History of prior radiotherapy Diagnosed with diabetes mellitus Presence of salivary gland tumors Renal or hepatic insufficiency Sepsis or any active systemic infection Distant metastases Any condition that may interfere with oral sample collection or affect EGF levels (e.g., autoimmune oral disease)

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced oral mucositis head and neck cancer Head and Neck Neoplasms stomatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral mucositis Oral mucositis due to radiation Radiation-induced oral mucositis

Contacts and locations

Locations

  • Faculty of Dentistry, Future University in Egypt

    Cairo, Cairo Governorate, 10226, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.