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Antibiotics or sugar pills? new study questions routine use after dental bone grafts

NCT ID NCT07296302

Disease control Sponsor: Agnaldo Rocha de Souza Junior Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares antibiotics (amoxicillin) to a placebo in 150 healthy adults undergoing dental bone grafting after tooth extraction. The goal is to see if antibiotics actually prevent infection or if placebo works just as well. Participants will be monitored for 30 days for infections and 6 months for bone healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Amoxicillin (or azithromycin for penicillin allergy)
What this could lead to
If successful, this could show that antibiotics are not needed for routine dental bone grafts, reducing unnecessary drug use and side effects.
What could go wrong
This is a small, early-stage trial with only 150 participants. The results may not apply to all patients, and there is a risk of infection in the placebo group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years. Generally healthy individuals classified as American Society of Anesthesiologists (ASA) physical status I or II ( ASA I or ASA II). Indication for tooth extraction followed by alveolar bone grafting in a fresh socket. Absence of active infection at the surgical site. Willingness to take amoxicillin or, in cases of β-lactam antibiotic allergy, azithromycin. No use of antibiotics in the previous 30 days. Agreement to participate and signature of the informed consent form (ICF). Exclusion Criteria: * Presence of uncontrolled systemic diseases or chronic use of immunosuppressive medications. Pregnancy or breastfeeding. Severe liver disease. Smoking more than 10 cigarettes per day. Known allergy to macrolides (azithromycin). Prior use of antibiotics within the last 30 days. Concomitant use of medications with known risk of QT interval prolongation. Signs of acute infection at the extraction site.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar ridge augmentation Antibiotic prophylaxis Bone grafting

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Universidade Estadual de Montes Claros - Unimontes

    Montes Claros, Minas Gerais, 39401-8321, Brazil

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