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Early antibiotics may cut pneumonia risk in trauma ICU patients

NCT ID NCT07059039

Prevention Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia. Researchers analyzed data from 2,143 adults admitted to intensive care after severe trauma. The goal was to see if early antibiotics reduce pneumonia cases in the first week on the ventilator.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotics (early systemic antibiotic prophylaxis)
What this could lead to
If effective, this could lead to a simple preventive strategy to reduce pneumonia in trauma patients on ventilators.
What could go wrong
This is a completed observational analysis, not a controlled trial, so results may not prove cause and effect. Antibiotics also carry risks like resistance and side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

2,143 people

The number who actually took part.

Started

Nov 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult trauma patients placed on mechanical ventilation during the first 24 hours of management, and for a duration of at least 48 hours

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patient * Trauma patient: admitted between 01/01/2021 and 31/12/2023 for suspected severe trauma (included in TraumaBase® ) * Put on mechanical ventilation during the first 24 hours following the start of medical care (including pre-hospital care) * Patient on MV for at least 48 consecutive hours during intensive care stay * Patient does not object to the use of his/her data for this research Exclusion Criteria: * Patient under full selective digestive decontamination protocol * Early inhaled antibiotic prophylaxis

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Conditions

The condition(s) this trial relates to.

injury pneumonia Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ventilator-associated pneumonia (VAP)

Contacts and locations

Locations

  • Hopital Beaujon

    Clichy, 92110, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.