Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Heart surgery antibiotic duration under scrutiny: could one dose be enough?

NCT ID NCT05447559

Disease control Sponsor: Monash University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares giving antibiotics only during heart surgery versus continuing for 24 or 48 hours afterward, to see if shorter use is just as good at preventing surgical site infections. Over 9,000 adults having heart surgery through a breastbone incision will take part. The goal is to reduce unnecessary antibiotic use, which can cause side effects and contribute to antibiotic resistance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cefazolin
What this could lead to
If successful, this could show that a single dose of antibiotic during surgery is enough to prevent infections, reducing side effects and antibiotic resistance.
What could go wrong
This is a large trial, but it's testing a non-inferiority approach—meaning it aims to prove shorter treatment is not worse. There is a risk that shorter treatment may lead to more infections in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 9,180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Adult patients undergoing cardiac surgery involving a median sternotomy Exclusion Criteria: * Age \<18 years * American Society of Anesthesiology (ASA) 5 * Subjects with GFR \<40mL/min/1.73m2 or those requiring continuous renal replacement therapy, haemodialysis or peritoneal dialysis * Surgery for suspected or proven endocarditis or deep sternal wound infection * Documented cefazolin hypersensitivity * Documented methicillin resistant Staphylococcus aureus (MRSA) colonisation or infection in the 12-months prior to index surgery * Cardiac transplantation * Procedures involving insertion ventricular assist device or mechanical circulatory support device * Procedures not involving a median sternotomy * Patients previously enrolled and randomised to the CALIPSO trial

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Surgical site infection are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgical site infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    25 sites in 5 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Austin Health

    RECRUITING

    Melbourne, Victoria, 3084, Australia

  • Cabrini Health

    RECRUITING

    Melbourne, Victoria, 3144, Australia

    Contact Email: •••••@•••••

  • Christchurch Hospital

    RECRUITING

    Christchurch, New Zealand

  • Epworth HealthCare

    RECRUITING

    Melbourne, Victoria, 3121, Australia

  • Fiona Stanley Hospital

    RECRUITING

    Perth, Western Australia, Australia

  • Flinders Medical Centre

    RECRUITING

    Adelaide, South Australia, 5042, Australia

  • Flinders Private

    RECRUITING

    Adelaide, South Australia, 5042, Australia

  • Halifax Infirmary

    RECRUITING

    Halifax, Nova Scotia, Canada

  • IJN

    RECRUITING

    Kuala Lumpur, Malaysia

  • Princess Alexandra Hospital

    RECRUITING

    Brisbane, Queensland, 4102, Australia

  • Royal Adelaide Hospital

    RECRUITING

    Adelaide, South Australia, 5000, Australia

  • Royal Hobart Hospital

    RECRUITING

    Hobart, Tasmania, 7000, Australia

    Contact Email: •••••@•••••

  • Sir Charles Gairdner

    NOT_YET_RECRUITING

    Nedlands, Western Australia, Australia

  • St Andrew's War Memorial Hospital

    ACTIVE_NOT_RECRUITING

    Brisbane, Queensland, Australia

  • St George Hospital

    ACTIVE_NOT_RECRUITING

    Sydney, New South Wales, 2217, Australia

  • St John of God Subiaco Hospital

    RECRUITING

    Perth, Western Australia, 6008, Australia

  • St Vincent's Hospital

    RECRUITING

    Melbourne, Australia

  • The Alfred Hospital

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • The Prince Charles Hospital

    RECRUITING

    Brisbane, Queensland, 4032, Australia

  • The Royal Melbourne Hospital

    RECRUITING

    Melbourne, Victoria, 3050, Australia

    Contact Email: •••••@•••••

  • UMMC

    NOT_YET_RECRUITING

    Kuala Lumpur, Malaysia

  • UT Southwestern Medical Centre

    NOT_YET_RECRUITING

    Dallas, Texas, 75390, United States

  • Victorian Heart Hospital

    RECRUITING

    Melbourne, Victoria, 3168, Australia

  • Waikato Hospital

    RECRUITING

    Hamilton, 3204, New Zealand

  • Wakefield Hospital

    NOT_YET_RECRUITING

    Wellington, New Zealand

  • Wellington Hospital

    RECRUITING

    Wellington, New Zealand

  • Westmead Hospital

    RECRUITING

    Sydney, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.