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Could an arthritis drug boost IVF success in endometriosis patients?

NCT ID NCT07509411

Disease control Sponsor: Benha University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study tests whether giving an anti-inflammatory drug (anti-TNFα) a few days before a frozen embryo transfer can help women with endometriosis who have had a failed IVF cycle get pregnant. The trial involves 145 participants and compares the clinical pregnancy rate to standard care. The goal is to see if reducing inflammation improves the womb's ability to accept an embryo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
TNF-α inhibitor (a drug that blocks inflammation)
What this could lead to
If it works, this could offer a new treatment option to improve pregnancy chances for women with endometriosis who have failed previous IVF attempts.
What could go wrong
This is a small, early-phase trial (145 participants) and results may not apply to all endometriosis patients. The drug may not improve pregnancy rates and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

145 people

The number who actually took part.

Started

Aug 2025

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Endometriosis diagnosed during infertility workup. * History of a previously failed ICSI trial. * Presence of more than one frozen embryo at the D-5 blastocyst stage qualified as good quality (Grade AA6). * Signed informed consent. Exclusion Criteria: * Polycystic Ovary Syndrome (PCOS). * Inflammatory disorders other than endometriosis. * Currently maintaining immune-modulating therapies for any other cause. * Refusal to participate.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis

Contacts and locations

Locations

  • Benha university

    Banhā, El Qalyoubia, 13511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.