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Pupil differences in ICU patients may reveal hidden brain clues

NCT ID NCT06964997

Knowledge-focused Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how often new pupil differences (one pupil larger than the other or not reacting normally) appear in adult intensive care patients. Researchers will review medical records from 2013 to 2024 to see what these changes mean for diagnosis, treatment, and patient outcomes. The goal is to better understand when a pupil change signals a serious problem and when it does not.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If patterns emerge, this could help doctors better understand when a pupil change signals a serious brain issue versus a harmless finding.
What could go wrong
This is a retrospective review of medical records, not a controlled experiment. It can show links but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

920 people

The number who actually took part.

Started

Mar 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients (i.e., patients ≥18 years of age) with a reported incident of pupillary abnormality (either anisocoria or non-normal pupillary reactivity) in the intensive care unit at the University Hospital Basel between 2013-2024.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (i.e., patients ≥18 years of age) * Reported incident of pupillary abnormality (either anisocoria or non-normal pupillary reactivity) in the intensive care unit at the University Hospital Basel between 2013-2024. Exclusion Criteria: * Patients younger than 18 years * Patients with documented refusal of data use.

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Conditions

The condition(s) this trial relates to.

anisocoria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anisocoria

Contacts and locations

Locations

  • University Hospital Basel, Clinic for Intensive Care Medicine

    Basel, Canton of Basel-City, 4031, Switzerland