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Anesthesia choice may influence lung cancer return, major trial investigates

NCT ID NCT06330038

Knowledge-focused Sponsor: Samsung Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large clinical trial is testing whether the type of anesthesia used during lung cancer surgery affects the chances of the cancer coming back. Over 5,000 people having surgery for early-stage non-small cell lung cancer will be randomly assigned to receive either intravenous propofol or inhaled gas anesthesia. The study will track cancer recurrence and survival for years after surgery to see if one method is better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Propofol and inhaled anesthetics (sevoflurane, desflurane, isoflurane)
What this could lead to
If it works, this could show that choosing a specific anesthesia type during lung cancer surgery helps reduce the chance of cancer coming back.
What could go wrong
This is a large, late-stage trial, but it's testing a subtle effect—anesthesia type may not significantly impact cancer recurrence. Results may not change standard practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 5,384 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists physical status (ASA) Ⅰ-Ⅲ * The Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Lung resection surgery (segmentectomy, lobectomy, bilobectomy, pneumonectomy; video-assisted, robot-assisted, or open) with curative intent for NSCLC (clinical Tumor, Node, Metastasis (TNM) stage Ⅰ- ⅢA). Exclusion Criteria: * Distant metastasis or malignant tumor in other organs that according to the attending surgeon is not in long-term remission * Severe neurologic conditions * Severe hepatic disease (Child-Pugh classification C) * Renal failure requiring renal replacement therapy * History of anesthesia and/or surgery within 1 yr * Previous surgery due to lung cancer (except diagnostic biopsies) * Contraindications to any study medication (history of allergy, hypersensitivity reaction, or any other contraindication) * Planned joint extrapulmonary procedure * Surgery under cardiopulmonary bypass or extracorporeal membrane oxygenation * Postoperative sedation * Pregnancy, or lactation * Patient refusal.

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Conditions

The condition(s) this trial relates to.

lung neoplasm Neoplasm Metastasis non-small cell lung carcinoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Non-small cell lung cancer Surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Samsung Medical Center

    RECRUITING

    Seoul, Seoul-teukbyeolsi, 06351, South Korea

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