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Shorter antibiotic course for lyme rash put to the test

NCT ID NCT03966014

Disease control Sponsor: University Medical Centre Ljubljana Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two treatment plans for people with erythema migrans, the classic Lyme disease rash. One group takes amoxicillin for 10 days, another for 14 days, and a third group gets no treatment. The goal is to see if a shorter course works just as well at preventing later symptoms. About 200 adults with the rash are being enrolled.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
amoxicillin
What this could lead to
If it works, this could show that a shorter course of amoxicillin is just as effective as a longer one for treating early Lyme disease.
What could go wrong
This is a moderate-sized trial, and the results may not apply to people with more advanced Lyme disease or other health conditions. Some patients may still have lingering symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2019

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * erythema migrans Exclusion Criteria: * pregnancy * extracutaneous manifestations of Lyme borreliosis * immunocompromising state * serious adverse event to beta lactam antibiotic * receiving antibiotic with antiborrelial activity within 10 days

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Conditions

The condition(s) this trial relates to.

fissured tongue Glossitis, Benign Migratory

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Erythema migrans

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Medical Centre Ljubljana

    RECRUITING

    Ljubljana, Slovenia

  • University Medical Centre Ljubljana

    NOT_YET_RECRUITING

    Ljubljana, Slovenia

More trials for these conditions

Other studies related to the condition(s) this trial covers.