Could a common pain pill calm Crohn's belly troubles even when inflammation is gone?

NCT ID NCT07556718

Not yet recruiting Symptom relief Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Apr 30, 2026 · Last updated May 19, 2026 · Updated 4 times

Summary

Many people with Crohn's disease still have belly pain, bloating, or diarrhea even when their disease is not active. This study tests whether a low dose of amitriptyline, a drug already used for irritable bowel syndrome, can safely reduce those symptoms. About 100 adults with quiet Crohn's will receive either amitriptyline or a placebo for several weeks. The main goal is to check safety and see if symptoms improve.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Contact

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Locations

University of Michigan

Ann Arbor, Michigan, 48109, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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QUIESCENT CROHN'S DISEASE (CD)