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Global survey reveals how ICUs use powerful antibiotics

NCT ID NCT02850029

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study surveyed 964 intensive care patients across multiple countries to understand how doctors currently prescribe and monitor aminoglycoside antibiotics (tobramycin, amikacin, gentamicin). Researchers collected data on dosing, therapy duration, and drug monitoring during the first week of treatment. The goal was to describe real-world practices, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this survey could help identify gaps and improve how aminoglycoside antibiotics are dosed and monitored in critically ill patients.
What could go wrong
This is an observational study, not a treatment trial. It only describes current practices and does not test any new intervention or directly improve patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

964 people

The number who actually took part.

Started

May 2016

Finished

Dec 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Large cohort of intensive care units patients receiving aminoglycosides (tobramycin, amikacin or gentamicin) as part of their antimicrobial therapy for sepsis.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old * Intensive care unit patients * Receiving aminoglycoside therapy for a sepsis according to the Third International Consensus Definitions for Sepsis and Septic Shock Exclusion Criteria: * Aged \< 18 years of age * Previous inclusion in the study

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Underdosing of aminoglycosides

Contacts and locations

Locations

  • AP-HM - Hopital Nord

    Marseille, 13915, France

  • AP-HP - Bicetre

    Paris, 94275, France

  • AP-HP - Hopital Paris St Antoine

    Paris, 75012, France

  • AP-HP - Paris St Louis

    Paris, 75010, France

  • APHM La timone

    Marseille, PACA, 13000, France

  • APHP- Bichat

    Paris, 75018, France

  • APHP- Descartes

    Paris, 75908, France

  • APHP-Hopital Georges Pompidou

    Paris, 75908, France

  • Aphm- La Conception

    Marseille, 13385, France

  • Aphp - Pitie Salpetriere

    Paris, 75013, France

  • Aphp- Pitie Salpetriere

    Paris, 75013, France

  • Athens Hippocratio Hospital

    Athens, Greece

  • CHI Robert Ballanger

    Aulnay-sous-Bois, 93602, France

  • CHU CAEN

    Caen, 14033, France

  • CHU La Reunion-Hopital Felix Guyon

    Saint-Denis, 97400, France

  • CHU MONTPELLIER-Hopital Lapeyronnie

    Montpellier, 34295, France

  • CHU MONTPELLIER-Hopital St Eloi

    Montpellier, 34295, France

  • CHU NANTES- hôpital Nord Laennec

    Nantes, 44093, France

  • CHU Nice- Hopital Pasteur

    Nice, 06001, France

  • CHU Nice-Hopital L'Archet

    Nice, 06202, France

  • CHU REIMS- Hopital Robert Debré

    Reims, 51100, France

  • CHU RENNES - Hopital Pontchaillou

    Rennes, 35033, France

  • CHU ROUEN- Hopital Nicolle

    Rouen, 76031, France

  • CHU SAINT-ETIENNE - Hopital Nord

    Saint-Etienne, 42270, France

  • CHU TOULOUSE- Hopital Rangueil

    Toulouse, 31059, France

  • Centre Hospitalier Aix-En-Provence

    Aix-en-Provence, 13097, France

  • Centre Hospitalier Arles

    Arles, 13637, France

  • Centre Hospitalier Aurillac

    Aurillac, 15000, France

  • Centre Hospitalier Avignon

    Avignon, 84902, France

  • Centre Hospitalier Bourg En Bresse

    Bourg-en-Bresse, 01012, France

  • Centre Hospitalier Charleville-Mezieres

    Charleville-Mézières, 08011, France

  • Centre Hospitalier D'Ales

    Alès, 30100, France

  • Centre Hospitalier La Rochelle-Hopital Saint Louis

    La Rochelle, 17019, France

  • Centre Hospitalier Sainte Catherine

    Saint-Brieuc, 22027, France

  • Centre Hospitalier Sainte Catherine

    Saverne, 67703, France

  • Centre Hospitalier Sambre-Avesnois

    Maubeuge, 59600, France

  • Centre Hospitalier Valence

    Valence, 26953, France

  • Centre Hospitalier de BOULOGNE SUR MER

    Boulogne-sur-Mer, 62321, France

  • Centre Hospitalier de Compiegne

    Compiègne, 60200, France

  • Centre Hospitalier de MORLAIX

    Morlaix, 29672, France

  • Centre Hospitalier de Montauban

    Montauban, 82013, France

  • Centre Hospitalier de PAU

    Pau, 64046, France

  • Centre Hospitalier de Roanne

    Roanne, 42328, France

  • Centre Hospitalier de Rodez

    Rodez, 12027, France

  • Centre Hospitalier de Salon de Provence

    Salon-de-Provence, 13658, France

  • Centre Hospitalier de Toulon, Hopital Sainte Musse

    Toulon, 83056, France

  • Centre Hospitalier de Valenciennes

    Valenciennes, 59322, France

  • Centre Hospitalier du Mans

    Le Mans, 72037, France

  • Centre Universitaire de Nimes

    Nîmes, 30029, France

  • Chru Besancon

    Besançon, 25030, France

  • Chru Brest

    Brest, 29609, France

  • Chru Nancy -Hopital de Brabois

    Nancy, 54511, France

  • Chu Amiens

    Amiens, 80054, France

  • Chu Angers

    Angers, 49100, France

  • Chu Angers

    Angers, 49933, France

  • Chu Bordeaux

    Bordeaux, 33076, France

  • Chu Brest- Hopital Cavale

    Brest, 29609, France

  • Chu Clermont-Ferrand

    Clermont-Ferrand, 63000, France

  • Chu Grenoble

    Grenoble, 38043, France

  • Chu Lyon- Hopital La Croix Rousse

    Lyon, 69317, France

  • Chu Lyon- Lyon Sud

    Lyon, 69495, France

  • Chu Nantes- Hopital Hotel Dieu

    Nantes, 44035, France

  • Chu Poitiers

    Poitiers, 86021, France

  • Frankston Hospital Victoria

    Frankston, Australia

  • G. Gennimatas General Hospital

    Thessaloniki, Greece

  • Guy'S and St Thomas'

    London, United Kingdom

  • Hospital Barros Luco Trudeau

    Santiago, Chile

  • Hospital Base de Valvidia

    Valdivia, Los Ríos Region, Chile

  • Hospital CU Chile

    Santiago, Chile

  • Naval and Veterans Hospital of Athens

    Athens, Greece

  • Oxford Radcliffe Hospitals

    Oxford, United Kingdom

  • Royal Brisbane Women's Hospital

    Brisbane, Queensland, 4029, Australia

  • Royal Brisbane and Women's Hospital

    Brisbane, Australia

  • Salford royal

    Manchester, United Kingdom

  • Salvador Santiago Hospital

    Santiago, Chile

  • Sandwell and west Birmingham hospital

    Birmingham, United Kingdom

  • Sheffield Teaching Hospitals

    Sheffield, United Kingdom

  • Southampton University Hospitals

    Southampton, United Kingdom

  • St Helens and Knowsley Hospitals

    Prescot, United Kingdom

  • Sunshine Coast hospital

    Sunshine Coast, Australia

  • Toowoomba Hospital

    Toowoomba, Australia

  • University Critical Care Department Aghioi Anargyroi Hospital

    Athens, Greece

  • University Hospital Birmingham

    Birmingham, United Kingdom

  • University Hospital of South Manchester

    Manchester, United Kingdom

  • University Hospital of loannina

    Ioannina, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.