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Scientists hunt for ALS biomarkers in tiny muscle samples

NCT ID NCT02670226

Knowledge-focused Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to find biological markers (biomarkers) in muscle, blood, and cells to help diagnose amyotrophic lateral sclerosis (ALS) earlier and understand the disease better. Researchers analyzed samples from 37 adults with ALS using advanced techniques to look at molecules and gene activity. The goal was to identify patterns that could lead to a diagnostic test, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

37 people

The number who actually took part.

Started

Mar 2016

Finished

Dec 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Case group selection criteria: Inclusion Criteria: * Age ≥ 18 years and ≥ 75 years * ALS according to the El Escorial criteria * Patients affiliated to social security scheme * Informed consent signed by the patient Exclusion Criteria: * Pregnant or breastfeeding women * Contraindication to biopsy * Contraindication to local anesthesia * Treatment with oral or injectable anticoagulants, antiplatelet (except aspirin) * Unbalanced Diabetes * Systemic corticosteroid treatment * Treatment against cramps or twitching may affect muscle metabolism Control group selection criteria: Inclusion Criteria: * Age ≥ 18 years and ≥ 75 years * No neuronal disease * Patients affiliated to social security scheme * Informed consent signed by the patient Exclusion Criteria: * Pregnant or breastfeeding women * Contraindication to biopsy * Treatment with oral or injectable anticoagulants, antiplatelet (except aspirin) * Unbalanced Diabetes * Systemic corticosteroid treatment * Treatment against cramps or twitching may affect muscle metabolism

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amyotrophic lateral sclerosis

Contacts and locations

Locations

  • Service de Neurologie, CHRU de TOURS

    Tours, 37044, France

  • Service de chirurgie orthopédique et traumatologique, CHRU de TOURS

    Tours, 37044, France

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