Antioxidant shows promise in sepsis battle
NCT ID NCT06661993
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a supplement called alpha-lipoic acid could help critically ill patients with sepsis. Eighty adults with sepsis were randomly assigned to receive either the supplement or a placebo daily for seven days. Researchers measured organ function, inflammation, and recovery time to see if the supplement improved outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who will be diagnosed with sepsis or develop sepsis during their ICU length of stay * Age 18 year and older * Patient able to receive oral or enteral medication Exclusion Criteria: * Patients who will be diagnosed with septic shock * Female patients who are pregnant or lactating. * Participation in another clinical trial. * Current treatment with other medications that have antioxidant effects, such as vitamin C and vitamin E. * Allergy to LA or similar active agents (e.g., vitamin B), or previous intolerance to the recommended dose of LA
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Damanhour Teaching Hospital, General Organization for Teaching Hospitals and Institutes.
Damanhūr, Elbehairah, 31527, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a computer model speed up sepsis blood tests?