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Almonds may strengthen flu shot immunity in overweight adults

NCT ID NCT05031663

Knowledge-focused Sponsor: Loma Linda University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether eating almonds every day can improve the immune system's response to the flu vaccine in overweight middle-aged men and postmenopausal women. Participants either added almonds as a snack or avoided them for several weeks. Researchers measured immune cell activity and tracked respiratory infections to see if almonds made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
almonds
What this could lead to
If almonds improve immune response, this could point toward a simple dietary way to support vaccine effectiveness.
What could go wrong
This is a small, completed study with only 61 participants. Results may not apply to everyone, and almonds are not a treatment for any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

61 people

The number who actually took part.

Started

Aug 2021

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Overweight men and post menopausal women (Basal Metabolic Index 25-32) * Age limit between 40-70 years * Be able to commute to Loma Linda University Exclusion Criteria: * Intolerance or allergy to almonds * Bad dentures, inability to chew almonds * Regular intake of almonds and or other nuts * Use of immune boosting supplements * Exposure to antibiotics and corticosteroids immediately prior to study * Have received influenza vaccination in past 10 months * Uncontrolled chronic disease and psychiatric illness

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Immune response Inflammation

Contacts and locations

Locations

  • Loma Linda University School of Public Health

    Loma Linda, California, 92350, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.