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Can cycling unlock brain secrets in Parkinson's?

NCT ID NCT07442747

Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This study looks at people with advanced Parkinson's disease who already have a brain device (deep brain stimulation). Researchers want to understand how aerobic exercise—specifically cycling—changes movement, thinking, and brain activity. Thirty-six participants will do an eight-week cycling program, and the team will measure symptoms and brain signals to uncover the mechanisms behind exercise benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aerobic exercise (cycling)
What this could lead to
If it works, this could reveal how exercise improves Parkinson's symptoms, pointing toward better exercise-based therapies.
What could go wrong
This is a small, early-stage study (36 people) focused on understanding mechanisms, not testing a treatment. Results may not apply to all Parkinson's patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of Parkinson's disease * Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD * Clinically optimized DBS parameters for one month prior to enrollment * Ability to ambulate with or without an assistive device for 5 continuous minutes * Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments Exclusion Criteria: * Neurocognitive impairment that compromises the ability to provide informed consent * Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) * Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen: 1. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provided prior to participation. 2. Those who choose not to obtain physician clearance will not be eligible for participation. Those who do not receive physician clearance for high intensity exercise will not be eligible. * A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise * Current cardiac arrhythmia

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Conditions

The condition(s) this trial relates to.

Motor Activity Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep brain stimulation Parkinson's disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

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