Can a High-Tech CPR bundle boost heart restart rates?
NCT ID NCT07754656
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether an adapted CPR bundle can increase the chance of restarting the heart in adults who suffer cardiac arrest outside a hospital. Participants are randomly assigned to receive either standard advanced life support or a modified approach that includes mechanical chest compressions, head-up positioning, an impedance threshold device, continuous epinephrine infusion, and double defibrillation. The main question is whether this bundle leads to a higher rate of return of spontaneous circulation compared to standard care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Adapted CPR bundle including mechanical chest compressions, head-up CPR, impedance threshold device, arterial line, continuous epinephrine infusion, and double sequence defibrillation
- What this could lead to
- If successful, this could point toward a more effective CPR approach that improves survival from cardiac arrest.
- What could go wrong
- This is a single-center trial with 216 participants, so results may not apply broadly. The intervention is complex and may not improve outcomes over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 216 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Mar 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age\> 18 years * time of resuscitation \<21 minutes when enrollement starts Exclusion Criteria: * obvious pregnancy * contraindications for the use of Lucas 3 * time of resuscitation \>21 minutes and etCO2 \<15 mmHg upon arrival of the emergency physician on scene * Exclusion from the emergency physician from study due to futility.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Kepler University Hospital
RECRUITINGLinz, Upper Austria, 4020, Austria
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Spinal fluid and blood may reveal how the brain suffers after cardiac arrest
- Blood tests in the ambulance: a new study probes early brain injury markers