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Could zapping the brain rapidly reduce suicidal urges?

NCT ID NCT04197765

Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether a type of brain stimulation called accelerated continuous theta-burst stimulation (acTBS) can reduce suicidal thoughts in people hospitalized for depression. Forty inpatients will receive either real or sham (fake) stimulation up to 5 times a day for about a week. Researchers will track changes in suicidal thinking and mood using questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
accelerated continuous theta-burst stimulation (acTBS) using a transcranial magnetic stimulation device
What this could lead to
If it works, this could point toward a rapid, non-drug treatment to ease suicidal thoughts in people hospitalized with depression.
What could go wrong
This is a very small pilot study with only 40 people. It is too early to know if the treatment is effective or safe for wider use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Inpatients admitted for "suicidality" with a documented diagnosis of MDD 2. Between the ages of 18 and 65 3. No safety concerns endorsed on the Screening 13-item Questionnaire for rTMS Candidates16 4. Have not received single-pulse or repetitive-TMS in the past, i.e. considered "TMS naïve". Exclusion Criteria: * (1) lifetime diagnosis of schizophrenia, schizoaffective disorder, delusional disorder, current psychotic symptoms (2) a history of epilepsy or any other major neurological disorder (3) Any exclusion on the 13-item Questionnaire for rTMS Candidates (4) diagnosis of borderline personality disorder, assessed on a case by case basis (5) concomitant major unstable medical illness (6) current withdrawal from psychoactive substances (7) history of failed brain stimulation (i.e. rTMS, ECT, VNS, DBS, TNS in the past)

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Conditions

The condition(s) this trial relates to.

major depressive disorder Suicidal Ideation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Suicidality

Contacts and locations

Locations

  • Resnick Neuropsychiatric Hospital

    Los Angeles, California, 90025, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.