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Could a shot clear up acne? new mRNA vaccine trial begins

NCT ID NCT06316297

Disease control Sponsor: Sanofi Pasteur, a Sanofi Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 3 times

Summary

This study tests an experimental mRNA vaccine designed to treat moderate to severe acne in adults aged 18 to 45. The vaccine is given as up to three injections into the muscle. Researchers will monitor safety, immune response, and how well it reduces acne lesions. The trial involves 800 participants and includes a long-term follow-up to check for lasting effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acne mRNA vaccine
What this could lead to
If successful, this could lead to a new treatment option for moderate to severe acne that targets the underlying bacteria, potentially reducing the need for daily medications.
What could go wrong
This is an early phase 1/2 trial, so safety and effectiveness are not yet proven. The vaccine may cause side effects or fail to improve acne significantly. Results may not apply to all acne types or severities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, and laboratory tests as judged by the investigator * Clinical diagnosis of moderate or severe facial acne vulgaris with Investigator's Global Assessment (IGA) score of Moderate or Severe (grade 3 or grade 4 on the 5-grade IGA scale) and ≥ 25 non-inflammatory lesions (ie, open and closed comedones) and ≥ 20 inflammatory lesions (ie, papules and pustules) and ≤ 2 nodulocystic lesions (ie, nodules and cysts) Exclusion Criteria: Participants are excluded from the study if any of the following criteria apply: * Known or suspected congenital or acquired immunodeficiency; or receipt of immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy, within 6 months prior to the first study intervention administration; or long-term systemic corticosteroid therapy (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months) * Known systemic hypersensitivity to any of the study intervention components; history of a life-threatening reaction to the study interventions used in the study or to a product containing any of the same substances; any allergic reaction (eg, anaphylaxis) after administration of mRNA coronavirus disease 2019 (COVID-19) vaccine * Active nodulocystic acne, acne conglobate, acne fulminans, secondary acne (eg, chloracne, drug-induced acne) or other forms of acne (eg, acne mechanica) * Use of any acne-affecting treatment without an appropriate washout period * Receipt of any vaccine (other than the study vaccine) in the 4 weeks preceding any study intervention administration or planned receipt of any vaccine (other than the study vaccine) in the 4 weeks following any study intervention administration * Previous vaccination against C. acnes with an investigational vaccine * Receipt of immune globulins, blood or blood-derived products in the past 3 months * Self-reported or documented seropositivity for human immunodeficiency virus (HIV), hepatitis B virus, or hepatitis C virus. The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.

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Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acne

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    94 sites in 4 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AMR Chicago- Site Number : 8400019

    RECRUITING

    Oak Brook, Illinois, 60523, United States

  • Accel Research Sites - NeuroStudies- Site Number : 8400134

    RECRUITING

    Decatur, Georgia, 30030, United States

  • Accellacare - McFarland Clinic- Site Number : 8400045

    RECRUITING

    Ames, Iowa, 50010, United States

  • Advanced Medical Research Institute - Miami- Site Number : 8400100

    RECRUITING

    Miami, Florida, 33174, United States

  • Alliance Clinical - West Hills- Site Number : 8400131

    RECRUITING

    Los Angeles, California, 91307, United States

  • Alpine Research Association- Site Number : 8400050

    RECRUITING

    Layton, Utah, 84041, United States

  • Amicis Research Center, LLC- Site Number : 8400110

    RECRUITING

    Palmdale, California, 93551, United States

  • Artemis Institute for Clinical Research - San Diego - Washington Street- Site Number : 8400103

    RECRUITING

    San Diego, California, 92103, United States

  • Best Skin Research - Camp Hill- Site Number : 8400017

    RECRUITING

    Camp Hill, Pennsylvania, 17011, United States

  • Boeson Research - Missoula- Site Number : 8400069

    RECRUITING

    Missoula, Montana, 59804, United States

  • California Research Foundation- Site Number : 8400095

    RECRUITING

    San Diego, California, 92123, United States

  • Carbon Health - North Hollywood - NoHo West- Site Number : 8400076

    RECRUITING

    North Hollywood, California, 91606, United States

  • CenExel FCR Tampa- Site Number : 8400130

    RECRUITING

    Tampa, Florida, 33613, United States

  • CenExel JRB - Salth Lake City- Site Number : 8400128

    RECRUITING

    Salt Lake City, Utah, 84107, United States

  • Center for Clinical Studies - Houston - Binz Street- Site Number : 8400002

    RECRUITING

    Houston, Texas, 77004, United States

  • Center for Dermatology and Plastic Surgery- Site Number : 8400111

    RECRUITING

    Scottsdale, Arizona, 85260, United States

  • Chemidox Clinical Trials- Site Number : 8400075

    RECRUITING

    Lancaster, California, 93534, United States

  • Clinical Research Institute - Minneapolis- Site Number : 8400080

    RECRUITING

    Minneapolis, Minnesota, 55402, United States

  • Clinical Trials Management - Metairie- Site Number : 8400072

    RECRUITING

    Metairie, Louisiana, 70006, United States

  • Cope Family Medicine - Ogden Clinic- Site Number : 8400112

    RECRUITING

    Bountiful, Utah, 84010, United States

  • Cura Clinical Research - Oxnard- Site Number : 8400062

    RECRUITING

    Oxnard, California, 93030, United States

  • D&H Tamarac Research Center- Site Number : 8400121

    RECRUITING

    Tamarac, Florida, 33321, United States

  • DFW Clinical Trials- Site Number : 8400057

    RECRUITING

    Carrollton, Texas, 75010, United States

  • Dawes Fretzin Clinical Research- Site Number : 8400022

    RECRUITING

    Indianapolis, Indiana, 46256, United States

  • DelRicht Research - Lockhart Matter Dermatology & Aesthetic Center- Site Number : 8400046

    RECRUITING

    Prosper, Texas, 75078, United States

  • DelRicht Research - New Orleans 308- Site Number : 8400013

    RECRUITING

    New Orleans, Louisiana, 70115, United States

  • DelRicht Research - Thompson's Station- Site Number : 8400041

    RECRUITING

    Smyrna, Tennessee, 37167, United States

  • Delricht Research - Mt Pleasant Dermatology- Site Number : 8400047

    RECRUITING

    Mt. Pleasant, South Carolina, 29464, United States

  • Direct Helpers Research Center- Site Number : 8400118

    RECRUITING

    Hialeah, Florida, 33012, United States

  • Dr. Manuel J Hernandez Clinical Research and Associates, Inc.- Site Number : 8400106

    RECRUITING

    Miami, Florida, 33126, United States

  • Driven Research- Site Number : 8400135

    RECRUITING

    Coral Gables, Florida, 33134, United States

  • Empire Clinical Research - Pomona- Site Number : 8400055

    RECRUITING

    Pomona, California, 91767, United States

  • Encino Research Center- Site Number : 8400033

    RECRUITING

    Encino, California, 91436, United States

  • Encore Medical Research - Hollywood- Site Number : 8400122

    RECRUITING

    Hollywood, Florida, 33024, United States

  • Encore Medical Research of Boynton Beach- Site Number : 8400116

    RECRUITING

    Boynton Beach, Florida, 33436, United States

  • Encore Research Group-Jacksonville Center for Clinical Research- Site Number : 8400006

    RECRUITING

    Jacksonville, Florida, 32216, United States

  • Equity Medical - Bowling Green- Site Number : 8400093

    RECRUITING

    Bowling Green, Kentucky, 42104, United States

  • Genomics Medical Research- Site Number : 8400120

    RECRUITING

    Cutler Bay, Florida, 33157, United States

  • Health and Life Research Institute- Site Number : 8400070

    RECRUITING

    Miami, Florida, 33176, United States

  • HealthMed Clinical Center- Site Number : 8400071

    RECRUITING

    Coral Gables, Florida, 33134, United States

  • Inquest Clinical Research - Baytown - West Baker Road- Site Number : 8400115

    RECRUITING

    Baytown, Texas, 77521, United States

  • Investigational Site Number : 0360001

    RECRUITING

    Phillip, Australian Capital Territory, 2606, Australia

  • Investigational Site Number : 0360002

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • Investigational Site Number : 0360003

    RECRUITING

    Sydney, New South Wales, 2010, Australia

  • Investigational Site Number : 0360005

    RECRUITING

    Woolloongabba, Queensland, 4102, Australia

  • Investigational Site Number : 0360006

    RECRUITING

    Waitara, New South Wales, 2077, Australia

  • Investigational Site Number : 0360007

    RECRUITING

    Carlton, Victoria, 3053, Australia

  • Investigational Site Number : 0360008

    RECRUITING

    Kotara, New South Wales, 2289, Australia

  • Investigational Site Number : 0360009

    RECRUITING

    Melbourne, Victoria, 3124, Australia

  • Investigational Site Number : 1240001

    RECRUITING

    Barrie, Ontario, L4M 7G1, Canada

  • Investigational Site Number : 1240004

    RECRUITING

    Toronto, Ontario, M4E 1R7, Canada

  • Investigational Site Number : 1240006

    RECRUITING

    Edmonton, Alberta, T5J 3S9, Canada

  • Investigational Site Number : 1240007

    RECRUITING

    Québec, Quebec, G1W 4R4, Canada

  • Investigational Site Number : 1240008

    RECRUITING

    Sherbrooke, Quebec, J1G 1X9, Canada

  • Investigational Site Number : 1240009

    RECRUITING

    Montreal, Quebec, H1Y 3L1, Canada

  • Investigational Site Number : 6300002

    RECRUITING

    San Juan, 00909, Puerto Rico

  • K2 Medical Research - The Villages - Northeast 138th Lane- Site Number : 8400063

    RECRUITING

    Lady Lake, Florida, 32159, United States

  • Kaiser Permanente - Los Angeles Medical Center- Site Number : 8400058

    RECRUITING

    Los Angeles, California, 90027, United States

  • Kuchnir Dermatology & Dermatologic Surgery- Site Number : 8400096

    RECRUITING

    Marlborough, Massachusetts, 01752, United States

  • LA Universal Research Center- Site Number : 8400059

    RECRUITING

    Los Angeles, California, 90057, United States

  • Las Vegas Clinical Trials- Site Number : 8400056

    RECRUITING

    Las Vegas, Nevada, 89030, United States

  • Leading Edge Dermatology- Site Number : 8400077

    RECRUITING

    Plantation, Florida, 33317, United States

  • Lone Star Clinical Research - Katy- Site Number : 8400049

    RECRUITING

    Katy, Texas, 77450, United States

  • Louisiana Dermatology Associates- Site Number : 8400043

    RECRUITING

    Baton Rouge, Louisiana, 70809, United States

  • Lynn Institute of Oklahoma City- Site Number : 8400004

    RECRUITING

    Oklahoma City, Oklahoma, 73112, United States

  • MediSearch Clinical Trials- Site Number : 8400035

    RECRUITING

    Saint Joseph, Missouri, 64506, United States

  • MetroBoston Clinical Partners - Brighton- Site Number : 8400008

    RECRUITING

    Brighton, Massachusetts, 02135, United States

  • MetroMed Clinical Trials- Site Number : 8400054

    RECRUITING

    Chicago, Illinois, 60614, United States

  • Michigan Institute of Research- Site Number : 8400092

    RECRUITING

    Allen Park, Michigan, 48101, United States

  • Modern Research Associates- Site Number : 8400094

    RECRUITING

    Dallas, Texas, 75231, United States

  • NorthBay Clinical Research- Site Number : 8400066

    RECRUITING

    Santa Rosa, California, 95405, United States

  • NorthShore University Health System - Endeavor Health Medical Group - Skokie - Woods Drive- Site Number : 8400031

    RECRUITING

    Skokie, Illinois, 60077, United States

  • Northridge Clinical Trials - Northridge- Site Number : 8400053

    RECRUITING

    Northridge, California, 91325, United States

  • Nuline Clinical Trial Center- Site Number : 8400060

    RECRUITING

    Pompano Beach, Florida, 33060, United States

  • Optimum Clinical Trial Group- Site Number : 8400125

    RECRUITING

    Tampa, Florida, 33612, United States

  • Paradigm Clinical Research Centers- Site Number : 8400064

    RECRUITING

    La Mesa, California, 91942, United States

  • Peninsula Research Associates- Site Number : 8400102

    RECRUITING

    Rolling Hills Estates, California, 90274, United States

  • Private Practice - Dr. Francisco Badar- Site Number : 8400067

    RECRUITING

    Cerritos, California, 90703, United States

  • Private Practice - Dr. Lawrence J. Green- Site Number : 8400024

    RECRUITING

    Rockville, Maryland, 20850, United States

  • Profound Research - Dermatologist Medical Group of North County- Site Number : 8400099

    RECRUITING

    Oceanside, California, 92056, United States

  • Renstar Medical Research - Ocala - Northeast 1st Avenue- Site Number : 8400021

    RECRUITING

    Ocala, Florida, 34470, United States

  • Seattle Clinical Research Center- Site Number : 8400038

    RECRUITING

    Seattle, Washington, 98104, United States

  • SouthCoast Research Center- Site Number : 8400114

    RECRUITING

    Miami, Florida, 33136, United States

  • Springville Dermatology - Springville- Site Number : 8400113

    RECRUITING

    Springville, Utah, 84663, United States

  • Sunwise Clinical Research- Site Number : 8400108

    RECRUITING

    Lafayette, California, 94549, United States

  • The Education & Research Foundation- Site Number : 8400036

    RECRUITING

    Lynchburg, Virginia, 24501, United States

  • The Iowa Clinic West Des Moines Campus- Site Number : 8400084

    RECRUITING

    West Des Moines, Iowa, 50266, United States

  • Trial Management Associates - Wilmington - Floral Parkway- Site Number : 8400104

    RECRUITING

    Wilmington, North Carolina, 28403, United States

  • TrueBlue Clinical Research- Site Number : 8400016

    RECRUITING

    Tampa, Florida, 33609, United States

  • Universal Medical Research - Coral Gables- Site Number : 8400081

    RECRUITING

    Coral Gables, Florida, 33134, United States

  • Universal Medical and Research Center- Site Number : 8400079

    RECRUITING

    Homestead, Florida, 33030, United States

  • Vida Clinical Studies - Dearborn Heights- Site Number : 8400074

    RECRUITING

    Dearborn Heights, Michigan, 48127, United States

  • WellQuest Clinical- Site Number : 8400082

    RECRUITING

    Miami, Florida, 33176, United States

  • Zenith Clinical Research- Site Number : 8400127

    RECRUITING

    Hollywood, Florida, 33021, United States

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Other studies related to the condition(s) this trial covers.