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Acne pills may reshape your gut and skin bacteria

NCT ID NCT07544251

Knowledge-focused Sponsor: Integrative Skin Science and Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how two common acne antibiotics, sarecycline and doxycycline, change the bacteria living in your gut and on your skin. Researchers will track these changes in 30 people with acne over the treatment period. The goal is to understand which antibiotic is gentler on your body's natural bacterial balance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sarecycline and doxycycline
What this could lead to
If successful, this could help doctors choose acne treatments that minimize disruption to beneficial bacteria.
What could go wrong
This is a small, early-phase study with only 30 participants, so results may not apply broadly. It focuses on microbiome changes, not directly on acne improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

9 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\) Diagnosis of acne vulgaris with: * At least 10 inflammatory lesions (papules, pustules, and nodules) up to 100 noninflammatory lesions (open and closed comedones) * No more than 2 nodules on the face Exclusion Criteria: 1. Dermatological condition of face or facial hair that could interfere with clinical evaluations 2. Subjects who have used the following medications (topical refers only to the facial area) will not be eligible: 2a) Within 2 week prior to randomization: * Topical acne medications such as retinoids, antibiotics, hormonal modulators * Topical benzoyl peroxide * Topical anti-inflammatories and corticosteroids 2b) Within 4 weeks prior to randomization: * Systemic antibiotics * Systemic acne treatments * Oral probiotic supplement * Systemic corticosteroids 2c) Within 12 weeks prior to randomization: * Systemic retinoids 3\) Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study. 4\) Individuals who are pregnant or breastfeeding. 5\) Individuals on oral contraceptive pills or progesterone or estrogen containing therapies unless they have been on a stable dose for 2 months. 6\) Individuals on finasteride or dutasteride 7\) Current tobacco smoker or a tobacco smoking history that is greater than 5 pack-years.

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Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acne vulgaris

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Integrative Research Institute

    RECRUITING

    Sacramento, California, 95819, United States

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