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Brain may 'forget' to use healed leg after ACL surgery

NCT ID NCT04837417

Knowledge-focused Sponsor: Istituto Auxologico Italiano Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 10 people who had ACL knee surgery 6-18 months earlier. Researchers tested whether the brain unconsciously stops fully activating the quadriceps muscle on the injured side, a phenomenon called 'learned non-use.' They used electrical stimulation, balance tests, and brain magnetic stimulation to measure nerve and muscle activity. The goal was to understand why weakness persists even after healing, which could improve return-to-sport decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify better criteria for when it's safe to return to sports after ACL surgery, and point toward new rehab strategies.
What could go wrong
This is a very small, completed observational study with only 10 participants. Results may not apply to everyone and do not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

10 people

The number who actually took part.

Started

Jul 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The participants will be recruited by ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Presidio Ospedaliero Gaetano Pini, among those who underwent the surgical interventions in the Centre.

Ages

18 to 35 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * anterior cruciate ligament tear with arthroscopic reconstruction, between 6 and 18 months before the tests; * Tegner activity level \> 5; * Body Mass Index between 18 and 25; * voluntary knee extension of at least 70°; * ability to understand the instructions; * ability to wittingly sign the informed consent form. Exclusion Criteria: * other previous knee injuries or surgical interventions; * major procedures associated with the anterior cruciate ligament reconstruction: osteotomy, other ligaments reconstruction; * meniscectomy, with surgical removal of more than 30% of the meniscal volume or removal of the meniscal root; * comorbidities, such as: rheumatic diseases; other congenital or acquired neuromuscular pathologies; diabetes mellitus; osteoporosis; cancer; heart disease; history of epilepsy, endocranial hypertension; * first degree relatives affected by epilepsy; * current treatment with oral anticoagulant or antiplatelet therapy; * drug therapy, which could induce epileptic crisis; * history of high alcohol consumption; * implanted electro-sensitive devices; * implanted intracranial or intraocular metallic devices; * history of retinal detachment; * presence of cochlear implant.

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injuries

Contacts and locations

Locations

  • ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Presidio Ospedaliero Gaetano Pini

    Milan, Italy

  • Istituto Auxologico Italiano

    Milan, MI, 20121, Italy

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