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Knee study withdrawn before it even started

NCT ID NCT07058467

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to see if a hands-on knee joint manipulation could improve thinking and movement in people who had ACL reconstruction. It planned to enroll 30 adults aged 18-35 who were 4 months to 10 years past surgery. However, the study was withdrawn before any participants were enrolled, so no data was collected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Joint manipulation (manual therapy)
What this could lead to
If it had worked, this could have pointed toward a simple, drug-free way to improve reaction time and movement after ACL surgery.
What could go wrong
The study was withdrawn before any participants were enrolled, so no results are available. It was a small, early feasibility study, not designed to prove effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Aug 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provided informed consent prior to any study procedures that are performed. * Are between the ages of 18 and 35. * Have undergone ACLR surgery. All autograft and allograft types are accepted. * Are 4-months to 10-years post-ACLR. * Injured knee playing or training for sports (recreational or organized) or during physical activity. * Have been cleared by a physician to return to activities and/or participate in this study. * Are at least the minimally clinical important difference (MCID) above the normative reaction time average for our methods as established by previous literature in at least 1 reaction time task. Exclusion Criteria: * History of concussion in the past 3 months. * The participant is pregnant. * Have a neurological disorder, including epilepsy. * Currently injured or have injured their lower extremity in the past 3 months. * Had surgery on multiple ligaments when their ACL was injured.

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Conditions

The condition(s) this trial relates to.

Lacerations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament (ACL) tear Anterior cruciate ligament reconstruction rehabilitation

Contacts and locations

Locations

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

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