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Could a fiber byproduct rejuvenate aging arteries?

NCT ID NCT05424263

Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether taking acetate, a substance produced when the gut digests fiber, can improve blood vessel function in adults aged 50 and older. The study will give participants acetate or a placebo for 12 weeks and measure how well their arteries expand and relax. The goal is to see if acetate can reduce the stiffness and dysfunction that come with age, which may lower the risk of heart disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Calcium acetate oral solution
What this could lead to
If it works, acetate supplements could offer a simple way to improve blood vessel health and reduce heart disease risk in older adults.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. Acetate may cause digestive side effects or not improve vessel function as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

37 people

The number who actually took part.

Started

Sep 2022

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Able to provide informed consent; * Age 50+ years; * Serum phosphorus levels \>= 2.5 mg/dl at screening; * Habitual dietary fiber intake \<30 g/day for men or \<21 g/day for women, based on Block Fiber Screener conducted at screening; * Weight-stable in the 3 months prior to enrollment (self-report); * Willing to abstain from dietary supplements for 48 hours and from alcohol, tobacco, and cannabis products for 24 hours before all visits; Exclusion Criteria: * History of current serious, chronic clinical disease, e.g., cardiovascular disease, diabetes, liver disease, Alzheimer's disease and related dementias, cancer; * Major changes in health in the past 3 months, e.g., hospitalizations, major surgeries, significant changes in medications; * Currently taking calcium acetate or any other calcium supplementation; * Screening FMDba \> 8%; * Body mass index \> 40 kg/m\^2 at screening; * Regular vigorous/aerobic endurance \>4 bouts/week for \>30 min/bout at a workload of \>6 METS; * Any apparent dependence on or abuse of alcohol, tobacco, and cannabis products; * Pregnancy, breast-feeding, or plans to become pregnant during the duration of the study; * Any finding on the medical history, physical exam, or standard clinical blood labs that, in the opinion of the physician of record, would put the subject at increased risk with calcium supplementation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Vascular dilation Vascular stiffness

Contacts and locations

Locations

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

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