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Emergency room pain study: which drug works faster for chest pain?

NCT ID NCT06949059

Symptom relief Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two intravenous painkillers—acetaminophen and hydromorphone—in 30 adults with sudden, severe chest pain. Researchers will measure pain relief within 30 minutes and track safety. The goal is to find better ways to manage acute chest pain in the emergency room.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hydromorphone and acetaminophen
What this could lead to
If successful, this could show that hydromorphone is a safe and effective option for quickly easing acute chest pain in the emergency room.
What could go wrong
This is a very small, early-phase study with only 30 people. It is not designed to prove which drug is better, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Age 18-64 years old; 2. Gender is not limited; 3. Patients with acute chest pain, with the time from pain onset to visit the doctor ≤ 24 days; 4. Severe pain that requires the use of opioids to control as determined by emergency physicians; 5. Obtain informed consent from the patient or family members. Exclusion criteria: 1. Known allergy to hydromorphone or morphine; 2. Systolic blood pressure \<100 mmHg, oxygen saturation \<95%, pulse less than 60 beats/min; 3. Use of acetaminophen or nonsteroidal anti-inflammatory drugs in the past 8 hours; 4. Chronic pain, defined as pain lasting for more than 12 weeks; 5. Delirium, alcohol withdrawal symptoms or other drug intoxication; 6. Pregnant or lactating women; 7. Patients with mental or neurological diseases, cognitive and consciousness disorders and inability to express correctly; 8. Participating in any other research at the same time; 9. Factors that increase the risk of participating in the study (life-threatening chest pain patients who require rapid diagnosis or treatment intervention, such as resuscitation status, excluding chest pain caused by myocardial infarction), who are judged by the researchers to be unsuitable for inclusion in the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute chest pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nanjing Drum Tower Hospital

    RECRUITING

    Nanjing, Jiangsu, 210008, China

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