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Could a simple diet boost your metabolism? study investigates betaine and choline

NCT ID NCT06758856

Knowledge-focused Sponsor: University of Guelph Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at whether taking extra betaine (from sugar beets) and choline (from eggs) can improve markers of metabolic health in adults with overweight or obesity. 34 participants followed a controlled diet for 4 weeks. Researchers measured blood lipids, glucose, insulin, and other health indicators.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Betaine (from sugar beets) and choline (from eggs)
What this could lead to
If it works, this could point toward dietary recommendations to improve metabolic health in people with overweight or obesity.
What could go wrong
This is a small, completed study (34 people) that measured biomarkers, not health outcomes. Results may not apply to everyone and may show no clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Jan 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female participant of any race or ethnicity between 18-70 years of age (inclusive) at the time of informed consent * BMI between 25-35 kg/m2 * Non-smoker * Willing to consume 3 eggs per day for one dietary period of 4 weeks * Willing to avoid eggs during the rest of the study including washout period breaks except for eggs that are provided * Willing to fast before the baseline and dietary period lab visits * Willing to provide a 24-hr prior day food record at the dietary period lab visits * Willing to provide or collect biological specimen samples at the baseline and dietary period lab visits * Willing to follow the study protocol including maintaining usual lifestyle during the entire study Exclusion Criteria: * Male or female \< 18 years or \> 70 years of age at the time of consent * BMI \< 25 kg/m2; or BMI \> 35 kg/m2 * Pregnant or planning to become pregnant during the course of the study; currently breastfeeding or postpartum \< 6 months * Use of hormone therapy including birth control pills * Follows a vegan diet * Current smoker (any form of nicotine, e-cigarettes, etc) * Use of recreational drugs (may affect metabolic pathway for choline) * Presence of chronic illnesses, e.g., heart disease, diabetes, cancer, celiac disease, inflammatory bowel disease (Crohn's disease and ulcerative colitis), gastrointestinal liver or kidney diseases or alcoholism * Diagnosis of trimethylaminuria (genetic disorder affecting choline use in body) * Use of antibiotics in the last 2 months * Use of prebiotics, probiotics or dietary fiber (i.e., Metamucil) supplements in the last 2 months * Have allergies to eggs or any anaphylactic food allergies * Have a schedule or lifestyle patterns incompatible with the study protocol

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Conditions

The condition(s) this trial relates to.

Obesity Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity and obesity-related medical conditions

Contacts and locations

Locations

  • Human Nutraceutical Research Unit

    Guelph, Ontario, N1G 2W1, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.