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New pill for early Alzheimer's shows promise in small trial

NCT ID NCT05771428

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tested an experimental drug called ABBV-552 in 263 people with mild Alzheimer's disease. Participants took either the drug or a placebo daily for 12 weeks. The goal was to see if the drug could safely improve memory and thinking. The results will help decide if larger studies are worthwhile.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ABBV-552 (oral capsule)
What this could lead to
If successful, this could point toward a new treatment to ease cognitive symptoms in early Alzheimer's disease.
What could go wrong
This is an early Phase 2 trial with only 263 participants over 12 weeks. The drug may not improve cognition or could cause side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

263 people

The number who actually took part.

Started

Jun 2023

Finished

Sep 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of probable Alzheimer's disease according to the National Institute of Aging-Alzheimer's Association (NIA-AA) (2011) criteria. * Mini-Mental State Examination (MMSE) score of 20 to 26, a Clinical Dementia Rating (CDR) global score of 0.5 or 1.0, with a CDR memory score of 0.5 or higher, and at least 1 CDR functional domain (community affairs, home and hobbies, or personal care) score of 0.5 or higher at Screening Visit 1. Exclusion Criteria: \- Clinically significant and/or unstable medical conditions or any other reason that the investigator determines would interfere with participation in this study (e.g., unlikely to adhere to the study or procedures, keep appointments, or is planning to relocate during the study) or would make the participant an unsuitable candidate to receive ABBV-552.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer's disease(AD)

Contacts and locations

Locations

  • ANESC Research LLC /ID# 246958

    El Paso, Texas, 79912, United States

  • Adams Clinical /ID# 248358

    Watertown, Massachusetts, 02472, United States

  • Alliance for Research Alliance for Wellness /ID# 246492

    Long Beach, California, 90807, United States

  • Allied Biomedical Res Inst Inc /ID# 246971

    Miami, Florida, 33155, United States

  • Alzheimer's Research and Treatment Center - Stuart /ID# 246484

    Stuart, Florida, 34997-5765, United States

  • Alzheimer's Research and Treatment Center - Wellington /ID# 246491

    Wellington, Florida, 33414, United States

  • American Clinical Research Institute (ACRI) - Beavercreek /ID# 246930

    Beavercreek, Ohio, 45432-2886, United States

  • Australian Alzheimer's Res Fou /ID# 249097

    Nedlands, Western Australia, 6009, Australia

  • Box Hill Hospital /ID# 249095

    Box Hill, Victoria, 3128, Australia

  • CGM Research Trust /ID# 249439

    Christchurch Central, 8011, New Zealand

  • Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 248078

    Berlin, 12203, Germany

  • Clinica Universidad de Navarra - Pamplona /ID# 248415

    Pamplona, Navarre, 31008, Spain

  • Columbus Memory Center /ID# 249534

    Columbus, Georgia, 31909, United States

  • Combined Research Orlando Phase I-IV /ID# 247697

    Orlando, Florida, 32814, United States

  • Conquest Research /ID# 262078

    Winter Park, Florida, 32789, United States

  • Duplicate_Kawashima Neurology Clinic /ID# 253561

    Fujisawa-shi, Kanagawa, 251-0038, Japan

  • Duplicate_Summit Headlands LLC /ID# 250678

    Portland, Oregon, 97210, United States

  • Epic Medical Research /ID# 249141

    Red Oak, Texas, 75154-3981, United States

  • Finlay Medical Research - West Palm Beach /ID# 246970

    Greenacres City, Florida, 33467-2979, United States

  • Health Synergy Clinical Research LLC /ID# 247726

    Okeechobee, Florida, 34972-2568, United States

  • Hizen Psychiatric Center /ID# 252363

    Kanzaki-gun, Saga-ken, 842-0192, Japan

  • Hospital Internacional Ruber - Grupo Quiron Salud /ID# 248856

    Madrid, 28034, Spain

  • Hospital Universitari General de Catalunya /ID# 249100

    Sant Cugat del Vallès, Barcelona, 08195, Spain

  • Hospital Universitari Mútua Terrassa /ID# 248448

    Terrassa, Barcelona, 08221, Spain

  • Hospital Universitario Marques de Valdecilla /ID# 248454

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario de Salamanca /ID# 249101

    Salamanca, 37711, Spain

  • Indiana University Health, Inc. /ID# 248300

    Fort Wayne, Indiana, 46804, United States

  • Irvine Clinical Research /ID# 250030

    Irvine, California, 92614, United States

  • Ivetmar Medical Group, LLC. /ID# 247670

    Miami, Florida, 33155, United States

  • Josephson-Wallack-Munshower Neurology - Northeast /ID# 248554

    Indianapolis, Indiana, 46256, United States

  • Juntendo University Hospital /ID# 252373

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • K2 Medical Research - Ocoee /ID# 251029

    Ocoee, Florida, 34761-4547, United States

  • K2 Medical Research - Orlando - South Orlando Avenue /ID# 250904

    Orlando, Florida, 32751, United States

  • K2 Medical Research - The Villages /ID# 250820

    Lady Lake, Florida, 32159-8975, United States

  • Kerwin Medical Center /ID# 248662

    Dallas, Texas, 75231-4316, United States

  • NHO Hiroshima-Nishi Medical center /ID# 256947

    Otake-shi, Hiroshima, 739-0696, Japan

  • NHO Niigata National Hospital /ID# 254207

    Kashiwazaki-shi, Niigata, 945-8585, Japan

  • Nara Medical University Hospital /ID# 252564

    Kashihara-shi, Nara, 634-8522, Japan

  • NeuroClin Limited(Previously Glasgow Memory Clinic) /ID# 249787

    Motherwell, Lanarkshire, ML3 4UF, United Kingdom

  • NeuroMedical Clinic of Central Louisiana /ID# 246960

    Alexandria, Louisiana, 71301-3900, United States

  • NeuroScience Research Center - Canton /ID# 248552

    Canton, Ohio, 44718-2784, United States

  • Neurology Diagnostics - South /ID# 246931

    Dayton, Ohio, 45459-4296, United States

  • New England Institute for Clinical Research /ID# 246488

    Stamford, Connecticut, 06905, United States

  • New Horizon Research Center /ID# 248298

    Miami, Florida, 33165-3372, United States

  • New Life Medical Research Center - Hialeah /ID# 247536

    Hialeah, Florida, 33012, United States

  • Northwest Clinical Trials /ID# 248663

    Boise, Idaho, 83704, United States

  • Oita University Hospital /ID# 253679

    Yufu, Oita Prefecture, 879-5503, Japan

  • Re:Cognition Health - London /ID# 249005

    London, W1G 9JF, United Kingdom

  • Re:Cognition Health Birmingham /ID# 249796

    Birmingham, B16 8LT, United Kingdom

  • Re:Cognition Health Bristol /ID# 249795

    Bristol, BS32 4SY, United Kingdom

  • Sentara Neurology Specialists - Norfolk /ID# 248578

    Norfolk, Virginia, 23510-1065, United States

  • Shonan Kamakura General Hospital /ID# 256664

    Kamakura-shi, Kanagawa, 247-8533, Japan

  • Southern Neurology - Kogarah /ID# 249098

    Kogarah, New South Wales, 2217, Australia

  • St Pancras Clinical Research /ID# 249006

    London, EC2Y 8EA, United Kingdom

  • St Vincent's Centre for Applied Medical Research /ID# 249843

    Darlinghurst, New South Wales, 2010, Australia

  • Tandem Clinical Research, LLC /ID# 246973

    Marrero, Louisiana, 70072-3156, United States

  • Teikyo University Mizonokuchi Hospital /ID# 253259

    Kawasaki, Kanagawa, 213-8507, Japan

  • Universitaetsklinikum des Saarlandes /ID# 248077

    Homburg, Saarland, 66424, Germany

  • University of Kentucky Sanders-Brown Center on Aging /ID# 251139

    Lexington, Kentucky, 40504, United States

  • Vanderbilt Ingram Cancer Center /ID# 248801

    Nashville, Tennessee, 37232-0021, United States

  • Velocity Clinical Research - Hallandale Beach /ID# 246896

    Hallandale, Florida, 33009-4427, United States

  • Velocity Clinical Research, Inc /ID# 249837

    Raleigh, North Carolina, 27607, United States

  • Vertex Research Group Inc /ID# 248295

    Clermont, Florida, 34711-5037, United States

  • Wake Research - Pharmacology Research Institute (WR-PRI), LLC (Alamitos) /ID# 248891

    Los Alamitos, California, 90720, United States

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Other studies related to the condition(s) this trial covers.