Could a simple blood test tell us more about fever seizures in kids?
NCT ID NCT07660003
First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times
Summary
This study looks at whether children who have seizures with fever show signs of DNA damage in their blood. Researchers measure a substance called 8-OHdG, which is a marker of oxidative stress, in children with simple or complex febrile seizures and compare it to healthy children. The goal is to see if this marker can help tell the difference between seizure types. It is an early, exploratory study and not yet ready for use in clinics.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If 8-OHdG levels differ between simple and complex febrile seizures, it could point toward a blood test to help classify seizure types.
- What could go wrong
- This is a small, exploratory study measuring a single biomarker at one time point. The findings may not be strong enough to guide diagnosis or treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
156 people
The number who actually took part.
- Started
-
Sep 2021
- Finished
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Dec 2022
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Children aged 6 to 72 months presenting to the paediatric emergency department of Kayseri City Training and Research Hospital (Kayseri, Türkiye). Three groups: simple febrile seizure, complex febrile seizure, and age- and sex-matched healthy controls. Participants were enrolled prospectively by convenience sampling from consecutive eligible admissions.
- Ages
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6 to 72 months
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age between 6 and 72 months 2. Presentation with a febrile seizure (simple or complex) to the paediatric emergency department, OR healthy age- and sex-matched child (control group) 3) For seizure groups: a seizure occurring in the context of fever, meeting clinical criteria for simple or complex febrile seizure 4\) Serum sample obtainable within 24 hours of seizure onset (seizure groups) Written informed consent provided by a parent or legal guardian Exclusion Criteria: 1. Central nervous system (CNS) infection (e.g., meningitis, encephalitis) 2. Known epilepsy or prior afebrile seizures 3. Neurodevelopmental delay 4. Chronic systemic illness 5. Use of antioxidant supplements within the preceding 3 months 6. Incomplete clinical or laboratory data
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kayseri City Hospital
Kayseri, 38090, Turkey (Türkiye)
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