Could a sugar imposter stop seizures?
NCT ID NCT05605301
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested how a pill called 2-deoxy-D-glucose (2DG) is absorbed and processed in 9 adults with epilepsy. 2DG is similar to sugar but can't be used for energy, so it may 'clog' the brain's fuel supply during a seizure and stop it. Researchers measured drug levels in the blood after different doses to understand safety and dosing.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 2-deoxy-D-glucose (2DG)
- What this could lead to
- If successful, this could point toward a new way to stop seizures by blocking the brain's energy use during a seizure.
- What could go wrong
- This is a very small, early-phase study with only 9 people, focused on drug levels and safety, not on stopping seizures. It may not lead to an effective treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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9 people
The number who actually took part.
- Started
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Sep 2022
- Finished
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Feb 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Confirmed diagnosis of epilepsy. For the purpose of inclusion, the seizure types include complex partial, simple partial motor, primary generalized tonic-clonic, secondary generalized tonic-clonic, tonic, clonic and atonic seizures, as well as simple partial and absence seizures. * Stable treatment regimen with no change in antiepileptic drugs or antiepileptic drug doses for 28 days prior to enrollment. * Women of childbearing potential must be using a standard method of birth control and agree not to become pregnant during the trial. Men must agree to not father a child during the trial. * BMI must be between 18 and 35. Exclusion Criteria: * Occurrence of non-epileptic psychogenic spells within 2 years prior to enrollment. * Current or past history of diabetes or any abnormality of glucose metabolism. * Use of glucocorticoids, hypoglycemic agents (e.g. metformin) or any drug that alters glucose levels. * Use of any drug that is expected to alter glucose absorption, metabolism or serum measurements. * Clinically significant psychiatric or medical disease. * Previous therapeutic use of 2DG. * Pregnant or nursing women. * Use of an investigational medication within 2 months prior to enrollment. * Supine systolic blood pressure \< 90 or \> 160 mm Hg or diastolic \> 90 mm Hg, or pulse \< 60 or \> 110 BPM. * Clinically significant abnormal 12-lead ECG. * Baseline prolongation of the QTc interval \> 450 msec. * Clinically significant abnormal result by speckle tracking echocardiography (STE). * Elevated ALT or AST more than 1.5 times upper reference limit. * Baseline fasting glucose \< 60 or \> 110. * History of status epilepticus within 6 months prior to enrollment. * Progressive structural brain lesion or illness likely to progress during the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Virginia School of Medicine
Charlottesville, Virginia, 22908, United States
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