Please sign in to follow a disease.
Could one month of blood thinners be enough after heart artery treatment?
NCT ID NCT07592507
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares 1 month versus the standard 6 months of dual antiplatelet therapy (two blood thinners) in people who had a balloon procedure for small coronary artery disease. About 1,484 adults with stable angina or silent ischemia will be randomly assigned to either short or standard therapy. The goal is to see if the shorter approach is just as good at preventing heart-related events while reducing bleeding risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 1,484 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
May 2026
An estimate. Start dates often move.
- Expected to finish
-
Feb 2032
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
19 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1)Adults aged 19 years or older 2)Subjects who have undergone drug-coated balloon (DCB) angioplasty 3) Subjects with stable angina, asymptomatic ischemia, and angiographically confirmed coronary lesions 4)Patients who have not undergone coronary intervention and whose coronary angiography demonstrates a reference vessel diameter between 2.0 mm and 3.0 mm, meeting all of the following conditions: No severe dissection corresponding to National Heart, Lung, and Blood Institute (NHLBI) grade C to F No reduction in coronary blood flow defined as TIMI flow grade \< 2 No residual stenosis ≥ 30% 5)Patients newly diagnosed with small-vessel coronary artery disease among those maintained on single antiplatelet therapy (SAPT) for at least 6 months after undergoing: de novo percutaneous coronary intervention (de novo PCI),in-stent restenosis PCI (ISR PCI), or percutaneous transluminal coronary angioplasty (PTCA) 6)Subjects who voluntarily agree to participate in this clinical study and provide written informed consent Exclusion Criteria: * 1\) Patients diagnosed with Acute Coronary Syndrome (ACS), including STEMI, NSTEMI, or Unstable Angina. 2\) Patients undergoing concomitant Percutaneous Coronary Intervention (PCI) during the Drug-Coated Balloon (DCB) procedure. 3\) Patients undergoing PCI for In-Stent Restenosis (ISR). 4) Patients with a diagnosis of active bleeding or coagulation disorder within 2 months prior to obtaining informed consent. 5\) Patients who underwent surgery with moderate-to-high risk within 6 weeks prior to obtaining informed consent. 6\) Patients with a history of intracerebral hemorrhage (ICH). 7) Patients with Hemoglobin \< 10 g/dL or Platelet count \< 100 x 10³/mm³. 8) Patients unable to discontinue oral anticoagulation therapy (OAC). 9) Patients on long-term treatment with NSAIDs or COX-2 inhibitors (excluding aspirin). 10\) Patients with a life expectancy of less than 1 year due to malignancy or other comorbidities. 11\) Patients with moderate-to-severe hepatic impairment. 12) Patients at risk of symptomatic bradycardia (e.g., 2nd-degree Mobitz Type II block or 3rd-degree AV block). 13\) Patients with dyspnea, such as those with Chronic Obstructive Pulmonary Disease (COPD). 14\) Patients with intolerance or hypersensitivity to the investigational medicinal products. 15\) Patients who participated in other clinical trials within 3 months prior to informed consent (excluding non-interventional observational studies). 16\) Women who are pregnant or breastfeeding. 17) Patients with End-Stage Renal Disease (ESRD) on hemodialysis or peritoneal dialysis, or those who have undergone a kidney transplant. 18\) Patients with rare hereditary metabolic disorders, such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. 19\) Any patient deemed unsuitable for participation in the clinical trial at the investigator's discretion.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Coronary artery disease are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Heart bypass surgeons test which vein layout keeps grafts open
- A soft patch that watches your heart beat in real time
- Zapping the ear: a new way to stop Post-Surgery heart rhythm problems?
- Squeeze a ball, lower your blood pressure? heart trial puts handgrip exercise to the test
- New heart scan aims to spot hidden plaque before it strikes
- Can a kidney ultrasound scan warn of kidney damage after heart bypass surgery?