University Of Oxford

This study tests whether giving a half-dose of the R21/Matrix-M malaria vaccine is as effective as the full dose in adults and teenagers aged 14 to 60. About 375 participants will be randomly assigned to receive either the standard dose or one of two half-dose versions. The goal …

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can improve symptoms in people experiencing their first episode of psychosis who haven't responded well to initial treatment. About 250 participants aged 16-40 will receive either CBD or a plac…

This study will follow about 2400 people in Thailand, Laos, and Cambodia to learn how the environment, the bacteria that cause melioidosis, and a person's health work together to cause disease. Researchers will track patients with melioidosis for one year, compare them to healthy…

This study aims to understand how the corpus luteum, a gland in the ovary that produces hormones in early pregnancy, affects the risk of developing preeclampsia—a serious condition causing high blood pressure. Researchers will measure hormone levels and use ultrasound to examine …

This study looks at how the antidepressant fluoxetine (Prozac) influences social thinking and decision-making in 80 healthy young people aged 18-24. Participants take either fluoxetine or a placebo for a week and complete tasks on emotion recognition, reward learning, and social …

This study involves 24 healthy adults in Thailand who will take three different malaria drugs—piperaquine, pyronaridine, and artesunate—alone and together. The goal is to see how these drugs interact in the body and check for side effects. Results will help doctors use these medi…