University Of Oxford

This study tests whether a half-dose of the R21/Matrix-M malaria vaccine is as effective as the full dose in 375 adults and adolescents aged 14 to 60. Participants will receive either the standard dose or a half-dose, and researchers will measure their immune response and safety.…

This phase II trial tests a new malaria vaccine called PvRII/Matrix-M in 36 healthy Thai adults aged 20-55. Half receive the vaccine, half a placebo. After three doses, 24 volunteers will be exposed to the malaria parasite in a controlled setting to see if the vaccine reduces inf…

This study tests a new experimental rabies vaccine (ChAdOx2 RabG) given together with the standard rabies vaccine in healthy adults aged 18-45. The goal is to see if this combination is safe and produces a strong immune response, potentially allowing a single visit instead of the…

This trial tests a web-based tool called PRADA that uses a person's genetics, symptoms, and preferences to help choose an antidepressant. Researchers will compare it to an older tool in adults with major depression across Ethiopia, Pakistan, and the UK. The goal is to see if the …

This study tests whether adding cannabidiol (CBD) to the standard drug clozapine helps people with treatment-resistant psychosis. 250 participants will receive either CBD or a placebo for 12 weeks. Researchers will measure symptom changes and check safety.

This study tests whether cannabidiol (CBD), a non-psychoactive cannabis compound, can reduce psychotic symptoms in 586 young people (ages 12-35) at high risk for psychosis. Participants take either CBD or a placebo daily for two years. The goal is to see if CBD can ease symptoms …

This trial explores whether a single dose of atomoxetine, a drug used for ADHD, can enhance motivation and information processing in healthy adults with varying levels of apathy. Participants will complete computer tasks measuring effort, reward, and decision-making after taking …

This early-stage trial will give 24 healthy adults three different malaria drugs—piperaquine, pyronaridine, and artesunate—alone and together to see how they interact. Researchers will measure drug levels in the blood and watch for side effects. The goal is to learn about safety …

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study from the University of Oxford will follow 360 pregnant women to see if hormone levels and ultrasound images from the first 8 weeks can predict pre-eclampsia. Pre-eclampsia is a dangerous complication that affects many pregnancies worldwide. The goal is to find early wa…

This study looks at why some people with hip impingement still have pain after doing physiotherapy exercises. Researchers will ask 175 adults about their emotions, fears, and pain types before and after treatment. The goal is to find hidden causes of pain, like nerve issues or an…

This study looks at how a week of Prozac (fluoxetine) changes decision-making and social thinking in 80 healthy people aged 18-24. Participants take either Prozac or a placebo, then complete tasks on emotion recognition, reward learning, and social exclusion. The goal is to bette…

This study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…