University Of Leicester

This study compares early valve replacement (surgery or TAVI) versus watchful waiting in people with severe aortic stenosis who have no symptoms. About 2,844 adults over 18 with severe but asymptomatic aortic stenosis will be followed for at least 3 years. The goal is to see if e…

This study explores whether CT and MRI scans can diagnose coronary microvascular disease (CMD), a condition where tiny heart vessels don't work properly, causing chest pain. Currently, diagnosis requires an invasive angiogram, which can be uncomfortable and risky. Researchers wil…

This study tests a new way to help people with Parkinson's improve their balance and reduce falls. Participants will play exercise video games while getting feedback on their brain activity to see if this combination works better than exercise alone. The study involves 100 people…

This study tests whether a 12-week low-calorie diet can improve heart function, reduce symptoms like breathlessness, and increase exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who also have obesity or type 2 diabetes. About 63 adults will …

This study looks at whether a remote exercise program is practical for women recovering from a spontaneous coronary artery dissection (SCAD), a type of heart attack that mainly affects otherwise healthy women. Researchers will recruit 120 women and track how many join, stick with…

This study tests if a wearable headband that uses sound waves and light can safely monitor blood flow in the brains of people who have had a stroke, as well as those with dementia, depression, or delirium. Researchers will also use artificial intelligence to analyze the data. Abo…

This study uses a new type of MRI scan with a special dye to look at how the heart works in people with heart failure with preserved ejection fraction (HFpEF), especially those who also have type 2 diabetes. The goal is to understand why this combination is so harmful. Researcher…

This study looks at whether having more fat around the heart makes heart function worse in people with a type of heart failure called HFpEF. Researchers will use CT and MRI scans, blood tests, and other checks in 130 obese and non-obese patients. The goal is to understand the rol…