University Hospitals, Leicester

This study looks at whether adding a human skin graft patch to standard rotator cuff repair reduces the chance of the tendon tearing again. About 40 people aged 50 to 75 with large tears will be randomly assigned to get surgery with or without the patch. All will have an MRI one …

This study tests a special blood filter (HA380) in 40 very ill adults who need dialysis or a heart-lung machine. The filter is designed to remove harmful inflammatory substances from the blood. Researchers want to see if using the filter is practical and if it can reduce time on …

This study compares a new pacing method called His bundle pacing to the standard right ventricular pacing in 100 adults with symptomatic atrial fibrillation and heart failure who are undergoing AV node ablation. The goal is to see if the new method improves walking distance, symp…

This study is testing whether a quick, non-invasive bedside device can accurately measure changes in body water content in pregnant women. Researchers will compare the device's readings to standard fluid charts in 900 participants, including those having planned C-sections, induc…

This study tracks how the COVID-19 pandemic affected RSV (a virus causing bronchiolitis) in UK children under 2. Researchers collect real-time reports from emergency departments and analyze virus samples to understand when RSV returns, how severe it is, and whether older children…

This study aims to find the genes responsible for bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their relatives to compare DNA. The goal is to better understan…