Sidney Kimmel Comprehensive Cancer Center At Thomas Jefferson University

This study tested whether giving nivolumab (an immunotherapy) along with chemotherapy before surgery could help shrink tumors in people with stage I to IIIA non-small cell lung cancer. The trial enrolled 14 patients whose cancer could be surgically removed. The goal was to see if…

This study tested a combination of precise radiation therapy and an eye injection drug (aflibercept) for people with a rare eye cancer called uveal melanoma. The goal was to see if this approach could control the tumor while reducing damage to healthy eye tissue. Only 3 people to…

This study looked at adding a new drug, ribociclib, to standard hormone therapy (enzalutamide) for men with advanced prostate cancer that had spread and stopped responding to hormone treatment. The goal was to find a safe dose and see if the combination could lower PSA levels. Th…

This study tested whether combining metformin (a diabetes drug) with doxycycline (an antibiotic) could help treat localized breast or uterine cancer. It involved 29 adults who were scheduled for surgery. The goal was to see if the drugs could change certain markers in the tumor's…

This study tested whether metformin (a diabetes drug) and doxycycline (an antibiotic) could help treat head and neck cancer when taken before surgery. Only 7 people enrolled before the study was stopped early. The main goal was to see changes in cancer-related proteins, not to cu…

This pilot study tested whether metformin, a common diabetes drug, could reduce side effects like dry mouth and taste changes from radioactive iodine treatment in people with thyroid cancer. It involved 13 participants who had their thyroid removed and were scheduled for radioact…