Northwestern University

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

This trial tests whether treadmill training with a robotic cable that gently pulls walkers side-to-side can improve balance and daily walking in adults who had a stroke. Participants complete 20 high-intensity treadmill sessions, either with the robotic pulling forces or without …

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. Instead of removing the whole cyst, doctors drain it and inject a solution to shrink it, which may better preserve a woman's egg supply. The study…

This trial tests whether nicotinamide riboside, a form of vitamin B3, can improve walking ability in people aged 50 and older with peripheral artery disease (PAD). Participants will take either the supplement or a placebo for six months. The main goal is to see if the supplement …

This early-phase trial tests whether adding the anti-inflammatory drug Anakinra to the solution that donor lungs are stored in can prevent primary graft dysfunction — a serious complication after lung transplant that causes low oxygen and lung inflammation. The study will enroll …

This study tests whether a single dose of valproic acid, given soon after a moderate to severe traumatic brain injury, can improve patients' recovery and reduce disability. About 432 adults aged 18 to 65 will be randomly assigned to receive either valproic acid (at a low or high …

This early-stage trial tests whether giving kidney transplant recipients a special treatment made from their donor's cells, combined with a light-based therapy called photopheresis, can safely reduce the risk of organ rejection. About 24 adults receiving their first kidney transp…

This phase II trial tests whether choosing chemotherapy based on a specific gene mutation (SMAD4) can improve outcomes for people with pancreatic cancer that is or may be surgically removable. The SMAD4 gene normally acts as a brake on tumor growth, but when it's mutated, tumors …

This early-phase trial tests whether low doses of erlotinib, a drug originally used for cancer, can improve symptoms of rare genetic skin conditions called keratinopathies. About 44 adults with confirmed diagnoses will take increasing doses over 24 weeks. The goal is to see if it…

This trial tests whether a social media campaign, co-created with young adult cancer survivors who are also online influencers, can improve how consistently adolescents and young adults (ages 15–25) with acute lymphoblastic leukemia take their daily oral chemotherapy. Participant…

This study compares two treatments for actinic keratoses—rough, scaly spots that can turn into skin cancer—on the arms. One treatment uses a light-sensitizing gel followed by blue light (photodynamic therapy), while the other uses a two-step chemical peel. About 60 adults with sp…

This phase II trial tests whether giving a mix of immunotherapy (durvalumab), chemotherapy (cisplatin and gemcitabine), and possibly a targeted drug (futibatinib) before surgery can improve outcomes for patients with resectable intrahepatic cholangiocarcinoma, a type of bile duct…

This early-phase trial tests whether adding the experimental drug futibatinib to standard chemotherapy (paclitaxel) and an antibody (ramucirumab) is safe for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery. The study…

This early-stage study tests a wound spray (APR-TD011) on skin lesions caused by cutaneous T cell lymphoma. Researchers want to see if the spray can reduce harmful bacteria (Staphylococcus aureus) on the skin and if it is well tolerated. The study will include 30 adults with earl…

Researchers are testing whether a brief firearm safety program called S.A.F.E. Firearm can change how patients store guns at home. The program pairs a short conversation about secure storage with an offer of a free cable lock. The trial runs in adult primary care and women's heal…

Researchers are testing whether a topical gel containing sirolimus can flatten raised epidermal nevi and even out their color. The study enrolls people aged 6 and older who have had stable, non-inflammatory epidermal nevi for at least three years. Participants apply the gel twice…

This study tests whether injecting alcohol or capsaicin near nerves can reduce long-term pain after amputation, including phantom limb pain and stump pain. About 120 adults with at least one leg amputation will receive alcohol injections; those with arm amputations will get capsa…

This study tests whether adding an injection of Xeomin (a type of botulinum toxin) to the erectile dysfunction pill tadalafil can improve erections better than the pill alone. About 30 men with mild-to-moderate ED will receive both treatments in a crossover design. The goal is to…

This study tests whether using a small vibration tool after wrist fracture surgery can reduce pain and the need for opioid painkillers. One hundred adults who have had surgery for a broken wrist will be randomly assigned to use the vibration tool or not. Researchers will measure …

This study tests a personalized approach for veterans with a lower leg amputation. Participants will try different prosthetic foot styles to find their favorite, then receive either standard care or a tailored physical therapy program. The goal is to see if this personalized plan…

This study looks at whether the Emsella chair, a non-invasive device that strengthens pelvic floor muscles, can reduce short-term stress urinary incontinence in men after prostate surgery for an enlarged prostate. Thirty men with moderate-to-large prostates will receive Emsella t…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This study investigates how axatilimab, an FDA-approved drug for chronic graft-versus-host disease (cGVHD), changes immune cells in the skin. Researchers will analyze skin and blood samples from 15 adults with skin cGVHD—10 starting axatilimab and 5 not receiving it—to understand…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study looks at whether it's possible to screen children for type 1 diabetes during their regular well-child visits. Researchers will ask parents and doctors about their experience with the screening and track how many families complete the test. The goal is to find the best …