Modernatx, Inc.

This study tests several updated mRNA COVID-19 vaccines designed to target new variants of the virus. About 1,100 adults and children with certain risk factors will receive one of the vaccines to see how well it boosts immunity and how safe it is. The goal is to ensure vaccines r…

This study tests an experimental mRNA vaccine (mRNA-1018-H5) designed to protect against a potential H5N1 bird flu pandemic. About 4,000 healthy adults aged 18 and older will receive two doses of the vaccine or a placebo. Researchers will measure how well the vaccine triggers an …

This early-stage study is testing a new mRNA vaccine called mRNA-1189 to see if it is safe and can protect against Epstein-Barr virus (EBV). About 120 healthy adults aged 18 to 30 will receive the vaccine either under the skin or into a muscle. Researchers will monitor side effec…

This study tests an updated COVID-19 vaccine (mRNA-1283) designed to protect against current virus variants. About 832 people aged 12 and older, especially those at higher risk, will receive the vaccine. Researchers will measure immune response and monitor for side effects to ens…

This study tests an experimental mRNA vaccine (mRNA-1982) designed to prevent Lyme disease, which is spread by tick bites. About 350 healthy adults aged 18 to 70 will receive either the vaccine or a placebo to check for safety and immune response. The goal is to find the best dos…

This study is testing the long-term safety of an mRNA therapy called mRNA-3705 in people with methylmalonic acidemia (MMA), a rare genetic disorder that prevents the body from breaking down certain proteins and fats. Participants have already been in earlier studies of this drug.…

This Phase 2 trial tests an experimental mRNA therapy called mRNA-1195 in 180 adults aged 18 to 55 with relapsing multiple sclerosis. Participants receive either the mRNA shot or a placebo, and researchers monitor safety and measure new brain lesions on MRI scans over about 2.5 y…

This study tests a new drug called mRNA-2808 in people with multiple myeloma that has returned or not responded to standard treatments. The drug is given through a vein and aims to control the cancer. The trial will check for side effects and measure how well the drug works. Abou…

This study looks at the long-term safety of an experimental medicine called mRNA-3927 for people with propionic acidemia, a rare genetic disorder that prevents the body from breaking down certain proteins and fats. About 50 participants who were in an earlier study will continue …

This study tests an experimental mRNA treatment, mRNA-4359, in people with advanced solid tumors that have not responded to standard therapies. The treatment is given alone or with other immune-boosting drugs. The main goals are to check safety and find the best dose. About 361 a…

This study tests an experimental mRNA therapy called mRNA-3927 for people with propionic acidemia, a rare genetic disorder that prevents the body from breaking down certain proteins and fats, leading to dangerous metabolic crises. The trial includes children and adults, with a se…

This study is not testing any new drug or treatment. Instead, researchers will look back at medical records of 60 people with propionic acidemia, a rare genetic disorder that affects how the body breaks down certain proteins and fats. The goal is to better understand the disease,…