Mario Negri Institute For Pharmacological Research

This study looks at whether adding olaparib to the standard drug bevacizumab can help keep advanced ovarian cancer from coming back after initial chemotherapy. About 190 women with a specific genetic marker (HRD-positive) will receive this combination as maintenance therapy. The …

This study looks back at medical records of 70 adults with advanced polycystic kidney disease (stage IV CKD) who are taking the drug octreotide LAR. The goal is to find out which early signs, like kidney size, best predict how fast kidney function will get worse over time. No new…

This study looks at 50 people with nephrotic syndrome to see which blood test — creatinine or cystatin C — better estimates actual kidney function. Researchers will compare these tests against a direct measurement of kidney filtration. The goal is to find a more reliable, non-inv…

This study looks at whether computer-generated health data can help researchers study autosomal dominant polycystic kidney disease (ADPKD) without needing as many real patients. Researchers will take real medical records from 100 adults with ADPKD and use AI to create fake but re…