Mario Negri Institute For Pharmacological Research

This study tests if a drug called patiromer can safely allow people on dialysis to eat more potassium-rich foods without dangerous side effects. About 40 adults on chronic dialysis will take either patiromer or a placebo. The goal is to see if the drug can relax strict diet rules…

This study tests whether giving people argon gas to breathe after a cardiac arrest can reduce brain and heart damage. Researchers will enroll 120 adults who were resuscitated from a witnessed cardiac arrest. The goal is to see if argon, which has shown protective effects in anima…

This study tests whether acetyl-L-carnitine, a natural supplement, can help people with ALS maintain their independence longer. About 246 adults with early-stage ALS will receive one of two doses of the supplement or a placebo for 48 weeks, alongside standard care. Researchers wi…

This study tests whether adding omega-3 fatty acids from fish oil or camelina oil to the diet can improve a blood-based risk score for heart disease. Researchers will enroll 324 adults over 55 at moderate to high cardiovascular risk. Participants will take one of three diets for …

This study looks at whether the sound made by blood flowing through an arteriovenous fistula (AVF) can tell doctors if the fistula is healthy. Researchers will measure blood flow conditions and compare them to the sounds recorded in 15 adults with end-stage kidney disease who nee…

This study looks at how immune cells differ in people with membranous nephropathy, a kidney disease. Researchers want to find out why some patients respond well to a treatment that depletes certain immune cells while others do not. They will compare blood samples from 86 patients…

This study follows 500 adults with a kidney condition called membranous nephropathy who are being treated with rituximab or similar drugs. Researchers will observe how well the disease responds over time and what factors predict better outcomes. The goal is to learn from real-wor…

This study is testing new ways to use an ultrasound machine to look at blood vessels in the arms and neck. Researchers will examine 60 healthy adults aged 18 to 75 to set up these new imaging methods and find normal ranges for measurements like blood vessel size and blood flow. T…