Kowa Research Institute

This phase 3 trial tests whether ripasudil (K-321) eye drops can improve corneal healing after cataract surgery. About 330 adults who have had cataract surgery will receive either the active eye drops or a placebo for 12 weeks, with a follow-up extension. The main goal is to see …

This study tests two doses of K-808 (Pemafibrate) in 46 adults with primary biliary cholangitis (PBC) who haven't responded well to standard treatments. The main goal is to see if the drug lowers alkaline phosphatase (ALP) levels, a key marker of liver damage, after 12 weeks. Par…

This completed Phase 2 study tested whether a combination of two experimental drugs, K-877-ER and CSG452, can improve liver health in adults with nonalcoholic steatohepatitis (NASH) and liver fibrosis. The 228 participants received either the combination or a placebo. The main go…

This study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea procedure called descemetorhexis. The trial involved 107 adults and compared the drops to a placebo over 12 weeks of treatment, fol…

This study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after combined cataract and cornea surgery. 110 adults received either the eye drops or a placebo for 12 weeks, followed by a taper and 38-week follow-up. …