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New eye drops aim to speed vision recovery after cornea surgery

NCT ID NCT05795699

Disease control Sponsor: Kowa Research Institute, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea procedure called descemetorhexis. The trial involved 107 adults and compared the drops to a placebo over 12 weeks of treatment, followed by a 2-week dose taper and 38 weeks of follow-up. The main goal was to see how quickly vision improved.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

107 people

The number who actually took part.

Started

Mar 2023

Finished

Feb 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Is at least 18 years old at the screening visit (Visit 1) * Has a diagnosis of FECD at Visit 1 * Meets all other inclusion criteria outlined in clinical study protocol Exclusion Criteria: * Is a female patient of childbearing potential and any of the following is true: 1. is pregnant or lactating/breastfeeding, or 2. is not surgically sterile, not post-menopausal (no menses for the previous 12 months), or not practicing an effective method of birth control as determined by the Investigator (eg, oral contraceptives, double barrier methods, hormonal injectable or implanted contraceptives, tubal ligation, or partner with vasectomy) * Has a study eye with a history of cataract surgery within 90 days of Visit 1 * Meet any other exclusion criteria outlined in clinical study protocol

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Conditions

The condition(s) this trial relates to.

Fuchs' endothelial dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fuchs endothelial corneal dystrophy

Contacts and locations

Locations

  • Aarhus Universitetshospital

    Aarhus N, Central Jutland, 8200, Denmark

  • Althaia Xarxa Assistencial Universitaria Manresa

    Manresa, Barcelona, 08243, Spain

  • Bascom Palmer Eye Institute

    Miami, Florida, 33418, United States

  • Bascom Palmer Eye Institute - Naples

    Naples, Florida, 34103, United States

  • Byers Eye Institute at Stanford

    Palo Alto, California, 94303, United States

  • Casey Eye Institute - OHSU

    Portland, Oregon, 97239, United States

  • Devers Eye Institute

    Portland, Oregon, 97210, United States

  • Dr. Greg Moloney

    Vancouver, British Columbia, V5Z 1K1, Canada

  • Eye Associates of New Mexico

    Albuquerque, New Mexico, 87109, United States

  • Eye Consultants of Atlanta

    Atlanta, Georgia, 30339-5971, United States

  • Gorovoy MD Eye Specialists

    Fort Myers, Florida, 33907, United States

  • Grene Vision Group

    Wichita, Kansas, 67208-3648, United States

  • Hospital Arruzafa

    Córdoba, Córdoba, 14012, Spain

  • Hospital Universitario Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Houston Eye Associates

    Houston, Texas, 77025, United States

  • Institut Catala de Retina (ICR)

    Barcelona, 08022, Spain

  • Instituto Oftalmologico Fernandez Vega

    Oviedo, Principality of Asturias, 33012, Spain

  • Instituto de Microcirugia Ocular

    Barcelona, 08035, Spain

  • Jules Stein Eye Institute

    Los Angeles, California, 90095, United States

  • Keck Hospital of USC

    Los Angeles, California, 90033, United States

  • LMU Klinikum der Universität

    München, 81377, Germany

  • Macy Eye Center

    Los Angeles, California, 90048, United States

  • Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, 02114, United States

  • Moorfields Eye Hospital

    London, London, City of, EC1V 2PD, United Kingdom

  • NYU Langone Health

    New York, New York, 10017, United States

  • Oftalvist - Barcelona

    Barcelona, 08017, Spain

  • Ottawa Hospital

    Ottawa, Ontario, K1H 8L6, Canada

  • Precision Cornea Centre

    Ottawa, Ontario, K1G 5L1, Canada

  • Prism Eye Institute - Mississauga-Oakville

    Oakville, Ontario, L6H 0J8, Canada

  • R and R Eye Research, LLC.

    San Antonio, Texas, 78229, United States

  • Rigshospitalet Glostrup-Nordre Ringvej 57

    Glostrup Municipality, Capital, 2600, Denmark

  • Royal Victoria Infirmary

    Newcastle upon Tyne, Northumberland, NE1 4LP, United Kingdom

  • Sacramento Eye Consultants

    Sacramento, California, 95815, United States

  • The Royal Liverpool University Hospital

    Liverpool, Lancashire, L7 8XP, United Kingdom

  • Uniklinik Köln

    Cologne, North Rhine-Westphalia, 50931, Germany

  • Universitatsklinikum Dusseldorf

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Universitatsklinikum Leipzig

    Leipzig, Saxony, 04103, Germany

  • Universitatsklinkum Erlangen-Ulmenweg 18

    Erlangen, Bavaria, 91054, Germany

  • University Hospitals Cleveland Medical Center - 11100 Euclid Ave

    Cleveland, Ohio, 44106, United States

  • University of Florida

    Gainesville, Florida, 32605, United States

  • University of Kentucky

    Lexington, Kentucky, 40508, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Wisconsin - 2870 University Ave

    Madison, Wisconsin, 53705, United States

  • Universität des Saarlandes

    Homburg, Saarland, 66424, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitätsklinikum Tübingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Vance Thompson Vision - Omaha

    Omaha, Nebraska, 68137, United States

  • Vance Thompson Vision West Fargo

    West Fargo, North Dakota, 58078, United States

  • Verdier Eye Center

    Grand Rapids, Michigan, 49546, United States

  • W Kellogg Eye Center

    Ann Arbor, Michigan, 48105, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.