Irccs Policlinico S. Donato

This study is testing a new heart valve device (Navitor/Navitor Vision) in 1,000 people with severe aortic stenosis, a condition where the heart's main valve narrows. The goal is to see how well the valve works in real-world settings by tracking survival and other outcomes over 1…

This study is testing a new device called the JenaValve Trilogy to replace the aortic valve in people with severe aortic regurgitation (a leaky heart valve) who are too high-risk for open-heart surgery. About 75 participants will receive the valve through a tube in an artery, avo…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery grows from the wrong spot, which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and predict wh…

This study observes 208 people with genetic aortic aneurysms to learn how lifestyle, stress, mental health, and other factors influence their condition. Researchers will track quality of life, awareness, and well-being. The goal is to better understand risk factors beyond traditi…

This study looks at how a gene called TMEM230 might be involved in atherosclerosis, the buildup of fatty plaques in arteries that can lead to heart attacks and strokes. Researchers will analyze gene activity in blood and artery samples from 12 adults undergoing vascular surgery. …

This study aims to find better, cheaper ways to detect Alzheimer's disease early in people who have memory complaints but still function normally. Researchers will collect blood, brain wave, and speech data, along with genetic information, and use machine learning to build a pred…

This study aims to improve how doctors analyze heart function using advanced MRI scans. Researchers will develop computer models to automatically measure heart chamber performance in 190 adults with severe aortic stenosis who are scheduled for valve replacement. The goal is to ma…

This study is developing an artificial intelligence system to automatically analyze 3D ultrasound images of the heart in people with mitral valve prolapse, a condition where a heart valve doesn't close properly. The goal is to create detailed 3D models of the valve to help doctor…

This study looks at pieces of the aorta removed during surgery from 40 people with aortic aneurysms. Researchers will test how strong the tissue is and how it stretches, hoping to link these findings to standard measurements like aortic size and wall thickness. The goal is to bet…

This study looks at how the brain, nervous system, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, heart rate control, and blood flow to see how these systems work together. The goal is to better understand why some people de…

This study looks at how stiff the arteries are in people who have a genetic condition that causes a bulge in the main artery (aortic aneurysm). Researchers want to see if measuring artery stiffness can help predict who is at higher risk. About 250 participants will have non-invas…

This study is testing whether adding genetic and imaging information to standard risk tools can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants are grouped by current risk level and followed for one year to see if the extra data leads to imp…