Intergroupe Francophone De Cancerologie Thoracique

This phase 2 study tests two targeted drugs, encorafenib and binimetinib, in 119 people with advanced non-small cell lung cancer that has a specific BRAF V600E mutation. The goal is to see if the combination can shrink tumors and keep them from growing. Participants take the pill…

This phase 2 trial is testing whether a chemotherapy combination without etoposide (carboplatin plus paclitaxel) plus the immunotherapy drug durvalumab works better than standard treatment for people with extensive-stage small cell lung cancer. About 67 participants will receive …

This phase 2 study tests whether adding chemotherapy to the targeted drug brigatinib helps people with advanced ALK-positive non-small cell lung cancer live longer without their cancer growing. About 110 people who have not had treatment for advanced disease will receive either b…

This study looks at whether adding the immunotherapy drug atezolizumab to standard chemotherapy helps elderly patients (70+) with advanced non-small cell lung cancer live longer. About 510 participants will receive either chemotherapy alone or chemotherapy plus atezolizumab. The …

This study tests whether adding an immunotherapy drug (atezolizumab) to a standard two-drug chemotherapy (paclitaxel and bevacizumab) can help people with advanced non-squamous lung cancer whose disease has worsened after prior immunotherapy and chemotherapy. About 156 participan…

This phase 2 trial tests the drug lorlatinib in 54 people with advanced ROS1-positive non-small cell lung cancer whose cancer has stopped responding to initial targeted therapy. Lorlatinib is designed to overcome resistance and reach the brain. Researchers will measure how many p…