Hoffmann-la Roche

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This study tests whether the drug divarasib can prevent lung cancer from coming back in people with a specific gene mutation (KRAS G12C) who have already had surgery and chemotherapy. About 400 adults with stage II-III non-small cell lung cancer will be randomly assigned to recei…

This study looks at the long-term safety and effectiveness of the drug afimkibart for people with moderate to severe rheumatoid arthritis who have not responded well to other treatments. It includes 120 adults who have already taken afimkibart in a previous study. The goal is to …

This study tests whether combining two experimental drugs, petrelintide and enicepatide, helps adults with obesity or overweight lose more weight than taking either drug alone or a placebo. About 486 participants will receive different doses or a placebo for several months. The g…

This early-stage study tests the safety and tolerability of a new drug, enicepatide, in 36 healthy Chinese adults with a BMI of 23 or higher. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and how the drug moves through the b…

This study will follow 30 children with Type I or Type II spinal muscle atrophy who are taking risdiplam. Researchers will track their motor skills and safety over 24 months using standard tests. The goal is to see how well the drug works in real-world settings, not just in contr…

This study will follow 3,000 people with COPD who have frequent flare-ups to see how the disease changes over time and what treatments they receive. Researchers will collect information from medical records and surveys to understand treatment patterns, quality of life, and caregi…