Gruppo Oncologico Del Nord-ovest

This study tests a combination of three drugs (trifluridine/tipiracil, capecitabine, and bevacizumab) in people with metastatic colorectal cancer who have not had chemotherapy for their advanced disease and are not eligible for intensive treatment. The goal is to find a safe dose…

This study tests whether giving a short course of chemo-immunotherapy before surgery can improve outcomes for people with Merkel cell carcinoma, a rare skin cancer. About 36 adults with operable tumors will receive one cycle of retifanlimab plus chemotherapy, then undergo surgery…

This study is for people with stage II or III colon cancer who are at high risk of the cancer coming back after surgery. Researchers are testing whether stronger chemotherapy (FOLFOXIRI) followed by an extra drug (Trifluridine/Tipiracil) can make cancer DNA in the blood disappear…

This study tests whether retreating with a combination of two targeted drugs (encorafenib and cetuximab) can shrink tumors in people with a specific type of advanced colorectal cancer (BRAF V600E mutation). Participants must have previously benefited from the same drugs and still…

This study compares two sequences of drugs (panitumumab followed by regorafenib versus the reverse order) in 214 patients with advanced colorectal cancer that no longer responds to standard treatments. Participants must have previously benefited from an anti-EGFR therapy and have…