Giselle Sholler

This study tests an oral drug called DFMO in children and young adults with high-risk neuroblastoma who are currently in remission. The goal is to see if taking DFMO for two years can prevent the cancer from coming back. About 441 participants will take the drug twice daily and b…

This study tests whether adding the drug naxitamab to standard chemotherapy helps children with newly diagnosed high-risk neuroblastoma. About 93 children will receive naxitamab during their first 5 rounds of chemo. The goal is to see if this combination leads to more complete re…

This study tests a combination of two drugs, DFMO and etoposide, in children and young adults (up to age 30) whose neuroblastoma has returned or not responded to standard treatment. The goal is to see if the combo can help them live longer without the cancer getting worse. About …

This study tests a new pill (tipifarnib) combined with an approved IV drug (naxitamab) for people with relapsed or hard-to-treat neuroblastoma. The goal is to see if the combination is safe and shrinks tumors or delays cancer growth. About 98 participants aged 1 to 21 at diagnosi…

This study tests a drug called DFMO (eflornithine) as a maintenance therapy to prevent relapse in children with high-risk or relapsed medulloblastoma, a type of brain cancer. About 118 children and young adults up to age 21 will take DFMO after standard treatment. The goal is to …

This study is for children newly diagnosed with high-risk neuroblastoma, a serious nerve tissue cancer. It first uses genetic tests to pick targeted drugs for each child's tumor during initial chemotherapy. Then, in a second phase, children are randomly assigned to receive standa…

This study offers expanded access to the drug DFMO for children and young adults (ages 0-30) with rare relapsed tumors like neuroblastoma or medulloblastoma that have certain genetic markers. The goal is to provide treatment when no other options are available, aiming to control …

This study is creating a large collection of tumor samples and health information from children and young adults with cancer, as well as survivors and healthy volunteers. Researchers will analyze the genetic makeup of the tumors to find patterns and potential targets for new trea…